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dc.contributor.authorHarris, Holly Ruth
dc.contributor.authorCramer, Daniel William
dc.contributor.authorVitonis, Allison F.
dc.contributor.authorDePari, Mary
dc.contributor.authorTerry, Kathryn Lynne
dc.date.accessioned2016-06-17T16:48:18Z
dc.date.issued2011
dc.identifier.citationHarris, Holly R., Daniel W. Cramer, Allison F. Vitonis, Mary DePari, and Kathryn L. Terry. 2011. “Folate, Vitamin B6, Vitamin B12, Methionine and Alcohol Intake in Relation to Ovarian Cancer Risk.” Int. J. Cancer 131 (4) (November 8): E518–E529. doi:10.1002/ijc.26455.en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27336524
dc.description.abstractFolate, methionine, vitamin B6, and vitamin B12 may influence carcinogenesis due to their roles in the one-carbon metabolism pathway which is critical for DNA synthesis, methylation, and repair. Low intake of these nutrients has been associated with an increased risk of breast, colon, and endometrial cancers. Previous studies that have examined the relation between these nutrients and ovarian cancer risk have been inconsistent and have had limited power to examine the relation by histologic subtype. We investigated the association between folate, methionine, vitamin B6, vitamin B12, and alcohol among 1910 women with ovarian cancer and 1989 controls from a case-control study conducted in eastern Massachusetts and New Hampshire from 1992 to 2008. Diet was assessed via food frequency questionnaire. Participants were asked to recall diet one-year before diagnosis or interview. Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (95% CIs). We also examined whether the associations varied by ovarian cancer histologies using polytomous logistic regression. We observed an inverse association between dietary vitamin B6 (covariate-adjusted OR=0.76, 95% CI 0.64–0.92; ptrend=0.002) and methionine intake (covariate-adjusted OR=0.72, 95% CI=0.60–0.87; ptrend<0.001) and ovarian cancer risk comparing the highest to lowest quartile. The association with dietary vitamin B6 was strongest for serous borderline (covariate-adjusted OR=0.49, 95% CI=0.32–0.77; ptrend=0.001) and serous invasive (covariate-adjusted OR=0.74, 95% CI=0.58–0.94; ptrend=0.012) subtypes. Overall, we observed no significant association between folate and ovarian cancer risk. One-carbon metabolism related nutrients, especially vitamin B6 and methionine, may lower ovarian cancer risk.en_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionofdoi:10.1002/ijc.26455en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288483/en_US
dash.licenseLAA
dc.subjectovarian canceren_US
dc.subjectfolateen_US
dc.subjectalcoholen_US
dc.subjectmethionineen_US
dc.subjectB-vitaminsen_US
dc.titleFolate, vitamin B6, vitamin B12, methionine and alcohol intake in relation to ovarian cancer risken_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalInternational Journal of Canceren_US
dash.depositing.authorCramer, Daniel William
dc.date.available2016-06-17T16:48:18Z
dc.identifier.doi10.1002/ijc.26455*
dash.contributor.affiliatedHarris, Holly R.
dash.contributor.affiliatedTerry, Kathryn
dash.contributor.affiliatedCramer, Daniel


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