Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort

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Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort

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Title: Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort
Author: Near, Aimee M.; Wu, Anna H.; Templeman, Claire; Van Den Berg, David J.; Doherty, Jennifer A.; Rossing, Mary Anne; Goode, Ellen L.; Cunningham, Julie M.; Vierkant, Robert A.; Fridley, Brooke L.; Chenevix-Trench, Georgia; Webb, Penelope M.; Kjær, Susanne Krüger; Hogdall, Estrid; Gayther, Simon A.; Ramus, Susan J.; Menon, Usha; Gentry-Maharaj, Aleksandra; Schildkraut, Joellen M.; Moorman, Patricia G.; Palmieri, Rachel T.; Ness, Roberta B.; Moysich, Kirsten; Cramer, Daniel William; Terry, Kathryn Lynne; Vitonis, Allison F.; Pike, Malcolm C.; Berchuck, Andrew; Pearce, Celeste Leigh

Note: Order does not necessarily reflect citation order of authors.

Citation: Near, Aimee M., Anna H. Wu, Claire Templeman, David J. Van Den Berg, Jennifer A. Doherty, Mary Anne Rossing, Ellen L. Goode, et al. 2011. “Progesterone Receptor Gene Polymorphisms and Risk of Endometriosis: Results from an International Collaborative Effort.” Fertility and Sterility 95 (1) (January): 40–45. doi:10.1016/j.fertnstert.2010.06.059.
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Abstract: Objective

To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism (SNP) and the PROGINS allele.

Design

Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies.

Setting

An international ovarian cancer consortium including studies from the Australia, Europe and the United States,

Patients

5,812 White female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies.

Interventions

None.

Main Outcome Measures

Genotypes for the +331C/T SNP and PROGINS allele and a history of endometriosis.

Results

The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (OR=0.65; 95% CI: 0.43–0.98, p=0.042), whereas there was no association between the PROGINS allele and endometriosis (OR=0.94, 95% CI 0.76, 1.16).

Conclusions

Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced PR-A to PR-B ratio and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.
Published Version: doi:10.1016/j.fertnstert.2010.06.059
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176720/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27336916
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