Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort
Near, Aimee M.
Wu, Anna H.
Van Den Berg, David J.
Doherty, Jennifer A.
Rossing, Mary Anne
Goode, Ellen L.
Cunningham, Julie M.
Vierkant, Robert A.
Fridley, Brooke L.
Webb, Penelope M.
Kjær, Susanne Krüger
Gayther, Simon A.
Ramus, Susan J.
Schildkraut, Joellen M.
Moorman, Patricia G.
Palmieri, Rachel T.
Ness, Roberta B.
Vitonis, Allison F.
Pike, Malcolm C.
Pearce, Celeste LeighNote: Order does not necessarily reflect citation order of authors.
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CitationNear, Aimee M., Anna H. Wu, Claire Templeman, David J. Van Den Berg, Jennifer A. Doherty, Mary Anne Rossing, Ellen L. Goode, et al. 2011. “Progesterone Receptor Gene Polymorphisms and Risk of Endometriosis: Results from an International Collaborative Effort.” Fertility and Sterility 95 (1) (January): 40–45. doi:10.1016/j.fertnstert.2010.06.059.
To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism (SNP) and the PROGINS allele.
Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies.
An international ovarian cancer consortium including studies from the Australia, Europe and the United States,
5,812 White female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies.
Main Outcome Measures
Genotypes for the +331C/T SNP and PROGINS allele and a history of endometriosis.
The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (OR=0.65; 95% CI: 0.43–0.98, p=0.042), whereas there was no association between the PROGINS allele and endometriosis (OR=0.94, 95% CI 0.76, 1.16).
Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced PR-A to PR-B ratio and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27336916
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