Genetic variation in telomere maintenance genes in relation to ovarian cancer survival

DSpace/Manakin Repository

Genetic variation in telomere maintenance genes in relation to ovarian cancer survival

Citable link to this page

 

 
Title: Genetic variation in telomere maintenance genes in relation to ovarian cancer survival
Author: Harris, Holly Ruth; De Vivo, Immaculata; Titus, Linda J.; Vitonis, Allison F.; Wong, Jason; Cramer, Daniel William; Terry, Kathryn Lynne

Note: Order does not necessarily reflect citation order of authors.

Citation: Harris, Holly R., Immaculata De Vivo, Linda J. Titus, Allison F. Vitonis, Jason YY Wong, Daniel W. Cramer, and Kathryn L. Terry. 2012. "Genetic variation in telomere maintenance genes in relation to ovarian cancer survival." International journal of molecular epidemiology and genetics 3 (3): 252.
Full Text & Related Files:
Abstract: Telomeres are repetitive non-coding DNA sequences at the ends of chromosomes that provide protection against chromosomal instability. Telomere length and stability are influenced by proteins, including telomerase which is partially encoded by the TERT gene. Genetic variation in the TERT gene is associated with ovarian cancer risk, and predicts survival in lung cancer and glioma. We investigated whether genetic variation in five telomere maintenance genes was associated with survival among 1480 cases of invasive epithelial ovarian cancer in the population-based New England Case-Control Study. Cox proportional hazard models were used to calculate hazard ratios and 95% confidence intervals. Overall we observed no significant associations between SNPs in telomere maintenance genes and mortality using a significance threshold of p=0.001. However, we observed some suggestive associations in subgroup analyses. Future studies with larger populations may further our understanding of what role telomeres play in ovarian cancer survival.
Published Version: http://www.ijmeg.org/files/IJMEG1207006.pdf
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459218/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27337012
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters