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dc.contributor.authorToumpoulis, Ioannis K.
dc.contributor.authorOxford, Julia Thom
dc.contributor.authorCowan, Douglas Burr
dc.contributor.authorAnagnostopoulos, Constantine E.
dc.contributor.authorRokkas, Chris K.
dc.contributor.authorChamogeorgakis, Themistocles P.
dc.contributor.authorAngouras, Dimitrios C.
dc.contributor.authorShemin, Richard J.
dc.contributor.authorNavab, Mohamad
dc.contributor.authorEricsson, Maria
dc.contributor.authorFederman, Micheline
dc.contributor.authorLevitsky, Sidney
dc.contributor.authorMcCully, James Donald
dc.date.accessioned2016-06-20T20:12:56Z
dc.date.issued2009
dc.identifier.citationToumpoulis, Ioannis K., Julia Thom Oxford, Douglas B. Cowan, Constantine E. Anagnostopoulos, Chris K. Rokkas, Themistocles P. Chamogeorgakis, Dimitrios C. Angouras, et al. 2009. “Differential Expression of Collagen Type V and XI ?-1 in Human Ascending Thoracic Aortic Aneurysms.” The Annals of Thoracic Surgery 88 (2) (August): 506–513. doi:10.1016/j.athoracsur.2009.04.030.en_US
dc.identifier.issn0003-4975en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27351948
dc.description.abstractBackground The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal process. Methods Surgical samples from ascending aortas from patients with degenerative ATAAs were subdivided by aneurysm diameter: small, 5 to 6 cm; medium, 6 to 7 cm; and large, greater than 7 cm; and compared with nonaneurysmal aortas (mean diameter, 2.3 cm). Results Histology, immunofluorescence, and electron microscopy demonstrated greater disorganization of extracellular matrix constituents in ATAAs as compared with control with an increase in collagen α1(XI) within regions of cystic medial degenerative lesions. Real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) showed collagens type V and α1(XI) were significantly and linearly increased in ATAAs as compared with control (p < 0.001). There was no change in the messenger ribonucleic acid (mRNA) expression levels of collagens type I and III. Western blot analysis showed collagens type I and III were significantly decreased and collagens α1(XI) and V were significantly increased and were linearly correlated with the size of the aneurysm (p < 0.001 for both). Conclusions These results demonstrate that increased collagen α1(XI) and collagen V mRNA and protein levels are linearly correlated with the size of the aneurysm and provide a potential mechanism for the generation and progression of aneurysmal enlargement.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.athoracsur.2009.04.030en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834780/en_US
dash.licenseLAA
dc.titleDifferential Expression of Collagen Type V and XI ?-1 in Human Ascending Thoracic Aortic Aneurysmsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalThe Annals of Thoracic Surgeryen_US
dash.depositing.authorMcCully, James Donald
dc.date.available2016-06-20T20:12:56Z
dc.identifier.doi10.1016/j.athoracsur.2009.04.030*
dash.authorsorderedfalse
dash.contributor.affiliatedFederman, Micheline
dash.contributor.affiliatedMcCully, James
dash.contributor.affiliatedEricsson, Maria
dash.contributor.affiliatedCowan, Douglas
dash.contributor.affiliatedLevitsky, Sidney


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