Eosinophils and disease pathogenesis

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Eosinophils and disease pathogenesis

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Title: Eosinophils and disease pathogenesis
Author: Akuthota, Praveen; Weller, Peter Fahey

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Citation: Akuthota, Praveen, and Peter F. Weller. 2012. Eosinophils and disease pathogenesis. Seminars in Hematology 49, no. 2: 113–119. doi:10.1053/j.seminhematol.2012.01.005.
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Abstract: Eosinophils are granulocytic innate immune cells whose presence is conspicuous in a variety of disease states, including eosinophilic hyperproliferative and infiltrative processes, as well as conditions associated with maladaptive Th2 inflammation. This review discusses the role of eosinophils in disease pathogenesis, including a consideration of relevant eosinophil biology. Eosinophilic disease patterns of tissue infiltration are also detailed, as are candidate mechanisms by which eosinophils cause fibrosis and hypercoagulability and the importance of eosinophils in allergic inflammation. Eosinophils are unique cells in their spectrum of associated disease, with the promise of future discoveries in delineating the manner in which they contribute to disease pathogenesis.
Published Version: doi:10.1053/j.seminhematol.2012.01.005
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571705/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27377616
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