LC/MS analysis of cellular RNA reveals NAD-linked RNA

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LC/MS analysis of cellular RNA reveals NAD-linked RNA

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Title: LC/MS analysis of cellular RNA reveals NAD-linked RNA
Author: Kowtoniuk, Walter; Agarwal, Isha; Shen, Yinghua; Liu, David Ruchien; Chen, Y. Grace

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Citation: Chen, Y Grace, Walter E Kowtoniuk, Isha Agarwal, Yinghua Shen, and David R Liu. 2009. LC/MS analysis of cellular RNA reveals NAD-linked RNA. Nature Chemical Biology 5, no. 12: 879–881. doi:10.1038/nchembio.235.
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Abstract: We developed a general method to detect cellular small molecule-RNA conjugates that does not rely on the reactivity of the small molecule, revealing NAD-linked RNA in E. coli and S. venezuelae. Subsequent characterization shows NAD is a 5’ modification of RNA, cannot be installed in vitro through aberrant transcriptional initiation, is only found among smaller cellular RNAs, and is present at a surprisingly high abundance of ~3000 copies per cell.
Published Version: doi:10.1038/nchembio.235
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842606/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27409160
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