HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
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Author
Suthanthiran, Manikkam
Shaffer, Juanita
Ding, Ruchuang
Sharma, Vijay
Hertl, Martin
Goes, Nelson B.
Wong, Waichi
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1056/NEJMoa071074Metadata
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Kawai, Tatsuo, A. Benedict Cosimi, Thomas R. Spitzer, Nina Tolkoff-Rubin, Manikkam Suthanthiran, Susan L. Saidman, Juanita Shaffer, et al. 2008. “HLA-Mismatched Renal Transplantation Without Maintenance Immunosuppression.” N Engl J Med 358, no. 4: 353–361. doi:10.1056/nejmoa071074.Abstract
Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient chimerism and reversible capillary leak syndrome developed in all recipients. Irreversible humoral rejection occurred in one patient. In the other four recipients, it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation, and renal function has remained stable for 2.0 to 5.3 years since transplantation. The T cells from these four recipients, tested in vitro, showed donor-specific unresponsiveness and in specimens from allograft biopsies, obtained after withdrawal of immunosuppressive therapy, there were high levels of P3 (FOXP3) messenger RNA (mRNA) but not granzyme B mRNA.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819046/Terms of Use
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