Dynamic development of the pancreas from birth to adulthood
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CitationBonner-Weir, Susan, Cristina Aguayo-Mazzucato, and Gordon C. Weir. 2016. “Dynamic development of the pancreas from birth to adulthood.” Upsala Journal of Medical Sciences 121 (2): 155-158. doi:10.3109/03009734.2016.1154906. http://dx.doi.org/10.3109/03009734.2016.1154906.
AbstractAfter birth the endocrine pancreas continues its development, a complex process that involves both the maturation of islet cells and a marked expansion of their numbers. New beta cells are formed both by duplication of pre-existing cells and by new differentiation (neogenesis) across the first postnatal weeks, with the result of beta cells of different stages of maturation even after weaning. Improving our understanding of this period of beta cell expansion could provide valuable therapeutic insights.
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