dc.contributor.author | Mullane, Stephanie A. | en_US |
dc.contributor.author | Werner, Lillian | en_US |
dc.contributor.author | Rosenberg, Jonathan | en_US |
dc.contributor.author | Signoretti, Sabina | en_US |
dc.contributor.author | Callea, Marcella | en_US |
dc.contributor.author | Choueiri, Toni K. | en_US |
dc.contributor.author | Freeman, Gordon J. | en_US |
dc.contributor.author | Bellmunt, Joaquim | en_US |
dc.date.accessioned | 2016-07-14T19:12:26Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Mullane, Stephanie A., Lillian Werner, Jonathan Rosenberg, Sabina Signoretti, Marcella Callea, Toni K. Choueiri, Gordon J. Freeman, and Joaquim Bellmunt. 2016. “Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma.” Scientific Reports 6 (1): 27702. doi:10.1038/srep27702. http://dx.doi.org/10.1038/srep27702. | en |
dc.identifier.issn | 2045-2322 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662055 | |
dc.description.abstract | Metastatic urothelial carcinoma (mUC) has a very high mutational rate and is associated with an APOBEC mutation signature. We examined the correlation of APOBEC expression with overall survival (OS) and PD-L1 expression in a cohort of 73 mUC patients. mRNA expression of APOBEC3 family of genes (A3A, A3B, A3C, A3F_a, A3F_b, A3G, A3H) was measured using Nanostring. PD-L1 expression, evaluated by immunohistochemistry, on tumor infiltrating mononuclear cells (TIMCs) and tumor cells was scored from 0 to 4, with 2–4 being positive. Wilcoxon’s non-parametric tests assessed the association of APOBEC and PD-L1. The Cox regression model assessed the association of APOBEC with OS. All APOBEC genes were expressed in mUC. Increased A3A, A3D, and A3H expression associates with PD-L1 positive TIMCs (p = 0.0009, 0.009, 0.06). Decreased A3B expression was marginally associated with PD-L1 positive TIMCs expression (p = 0.05). Increased A3F_a and A3F_b expression was associated with increased expression of PD-L1 on tumor cells (p = 0.05). Increased expression of A3D and A3H was associated with longer OS (p = 0.0009). Specific APOBEC genes have different effects on mUC in terms of survival and PD-L1 expression. A3D and A3H may have the most important role in mUC as they are associated with OS and PD-L1 TIMC expression. | en |
dc.language.iso | en_US | en |
dc.publisher | Nature Publishing Group | en |
dc.relation.isversionof | doi:10.1038/srep27702 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901342/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Scientific Reports | en |
dash.depositing.author | Signoretti, Sabina | en_US |
dc.date.available | 2016-07-14T19:12:26Z | |
dc.identifier.doi | 10.1038/srep27702 | * |
dash.contributor.affiliated | Choueiri, Toni | |
dash.contributor.affiliated | Bellmunt, Joaquim | |
dash.contributor.affiliated | Freeman, Gordon | |
dash.contributor.affiliated | Signoretti, Sabina | |