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dc.contributor.authorMullane, Stephanie A.en_US
dc.contributor.authorWerner, Lillianen_US
dc.contributor.authorRosenberg, Jonathanen_US
dc.contributor.authorSignoretti, Sabinaen_US
dc.contributor.authorCallea, Marcellaen_US
dc.contributor.authorChoueiri, Toni K.en_US
dc.contributor.authorFreeman, Gordon J.en_US
dc.contributor.authorBellmunt, Joaquimen_US
dc.date.accessioned2016-07-14T19:12:26Z
dc.date.issued2016en_US
dc.identifier.citationMullane, Stephanie A., Lillian Werner, Jonathan Rosenberg, Sabina Signoretti, Marcella Callea, Toni K. Choueiri, Gordon J. Freeman, and Joaquim Bellmunt. 2016. “Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma.” Scientific Reports 6 (1): 27702. doi:10.1038/srep27702. http://dx.doi.org/10.1038/srep27702.en
dc.identifier.issn2045-2322en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27662055
dc.description.abstractMetastatic urothelial carcinoma (mUC) has a very high mutational rate and is associated with an APOBEC mutation signature. We examined the correlation of APOBEC expression with overall survival (OS) and PD-L1 expression in a cohort of 73 mUC patients. mRNA expression of APOBEC3 family of genes (A3A, A3B, A3C, A3F_a, A3F_b, A3G, A3H) was measured using Nanostring. PD-L1 expression, evaluated by immunohistochemistry, on tumor infiltrating mononuclear cells (TIMCs) and tumor cells was scored from 0 to 4, with 2–4 being positive. Wilcoxon’s non-parametric tests assessed the association of APOBEC and PD-L1. The Cox regression model assessed the association of APOBEC with OS. All APOBEC genes were expressed in mUC. Increased A3A, A3D, and A3H expression associates with PD-L1 positive TIMCs (p = 0.0009, 0.009, 0.06). Decreased A3B expression was marginally associated with PD-L1 positive TIMCs expression (p = 0.05). Increased A3F_a and A3F_b expression was associated with increased expression of PD-L1 on tumor cells (p = 0.05). Increased expression of A3D and A3H was associated with longer OS (p = 0.0009). Specific APOBEC genes have different effects on mUC in terms of survival and PD-L1 expression. A3D and A3H may have the most important role in mUC as they are associated with OS and PD-L1 TIMC expression.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/srep27702en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901342/pdf/en
dash.licenseLAAen_US
dc.titleCorrelation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinomaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorSignoretti, Sabinaen_US
dc.date.available2016-07-14T19:12:26Z
dc.identifier.doi10.1038/srep27702*
dash.contributor.affiliatedChoueiri, Toni
dash.contributor.affiliatedBellmunt, Joaquim
dash.contributor.affiliatedFreeman, Gordon
dash.contributor.affiliatedSignoretti, Sabina


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