Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer

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Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer

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Title: Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer
Author: Gupta, Nisha; Duda, Dan G.

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Citation: Gupta, Nisha, and Dan G. Duda. 2016. “Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer.” Journal of Biomedical Research 30 (3): 181-185. doi:10.7555/JBR.30.20150114. http://dx.doi.org/10.7555/JBR.30.20150114.
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Abstract: Abstract Metastatic prostate cancer is one of the leading causes of cancer-related death in men. The primary site of metastasis from prostate cancers is the bone. During the last decade, multiple studies have pointed to the role of the stromal cell-derived factor 1 alpha (SDF1α)/CXCR4 axis in the metastatic spread of the disease, but the mechanisms that underlie this effect are still incompletely understood. In this review, we summarize the current understanding of the role of the SDF1α/CXCR4 pathway in bone metastatic prostate cancer. We also discuss the therapeutic potential of disrupting the interaction between prostate tumor cells and bone environment with focus on the SDF1α pathway.
Published Version: doi:10.7555/JBR.30.20150114
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885164/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662084
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