Zollinger-Ellison Syndrome Associated with von Recklinghausen Disease: Case Report and Literature Review

DSpace/Manakin Repository

Zollinger-Ellison Syndrome Associated with von Recklinghausen Disease: Case Report and Literature Review

Citable link to this page

 

 
Title: Zollinger-Ellison Syndrome Associated with von Recklinghausen Disease: Case Report and Literature Review
Author: Alshikho, Mohamad J.; Noureldine, Salem I.; Talas, Joud M.; Nasimian, Antoine; Zazou, Safi; Mobaed, Bashir; Nasser, Mahmoud

Note: Order does not necessarily reflect citation order of authors.

Citation: Alshikho, Mohamad J., Salem I. Noureldine, Joud M. Talas, Antoine Nasimian, Safi Zazou, Bashir Mobaed, and Mahmoud Nasser. 2016. “Zollinger-Ellison Syndrome Associated with von Recklinghausen Disease: Case Report and Literature Review.” The American Journal of Case Reports 17 (1): 398-405. doi:10.12659/AJCR.898472. http://dx.doi.org/10.12659/AJCR.898472.
Full Text & Related Files:
Abstract: Patient: Female, 28 Final Diagnosis: Gastrinoma Symptoms: Vomiting • diarrhea • epigastric soreness • heartburn • nausea • significant weight loss Medication: — Clinical Procedure: Esophagogastroduodenoscopy • blood tests • abdomen CT scan • surgery Specialty: Gastroenterology and Hepatology Objective: Rare co-existance of disease or pathology Background: Pancreatic endocrine tumors (PETs) are rare and can occur as part of neurofibromatosis type 1 (NF1). Gastrinomas are functional PETs that are rarely associated with NF1. Only two cases of their occurrence have been reported in the literature. Case Report: A 28-year-old woman was admitted for further evaluation of epigastric soreness, heartburn, nausea, vomiting, diarrhea, and a significant weight loss. Physical examination was remarkable for cutaneous findings (axillary freckling and multiple café-au-lait spots) as well as neurofibromas (dermal, plexiform). A diagnosis of NF1 was confirmed. Esophagogastroduodenoscopy (EGD) revealed multiple ulcers in the duodenum and the upper jejunum. A fasting gastrin level exceeded ten times the normal limit. An abdominal multi-slice 128 computed tomography (CT) scan revealed an oval mass of 26 mm in diameter adjacent to the second segment of the duodenum. The patient was examined carefully to rule out multiple endocrine neoplasia type 1 (MEN1). Surgical resection was performed and a gastrinoma, causing Zollinger-Ellison syndrome (ZES), was diagnosed by histological examinations of the extirpated mass. The serum gastrin level decreased to normal limits shortly after surgery. Continuous follow-up revealed that the symptoms and the EGD findings completely resolved without recurrences. Conclusions: Although NF1 has common skeletal, visual, neurological, and cardiovascular complications, it also has a rare association with duodenal or pancreatic gastrinomas. Vigilance for this possible association is important to promote timely and careful management to help eliminate serious and potentially life-threatening complications.
Published Version: doi:10.12659/AJCR.898472
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917078/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662089
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters