Cautionary optimism: caffeine and Parkinson’s disease risk

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Cautionary optimism: caffeine and Parkinson’s disease risk

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Title: Cautionary optimism: caffeine and Parkinson’s disease risk
Author: Sokol, Leonard L.; Young, Michael J.; Espay, Alberto J.; Postuma, Ronald B.

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Citation: Sokol, Leonard L., Michael J. Young, Alberto J. Espay, and Ronald B. Postuma. 2016. “Cautionary optimism: caffeine and Parkinson’s disease risk.” Journal of Clinical Movement Disorders 3 (1): 7. doi:10.1186/s40734-016-0037-8.
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Abstract: Most Parkinson’s disease (PD) patients present without known family history and without a diagnosed prodromal phase, underscoring the difficulty of employing primary (neuroprevention) and secondary (neuroprotection) preventions. In cases of monogenic forms, however, potential gene-carrying family members of a proband could engage in neuroprevention, such as exercise or diet modifications, to attenuate the risk of, or delay, disease development. However, a historical lack of recognized disease-modifying interventions has limited clinicians’ ability to recommend reliable preventive measures in caring for at-risk populations. We briefly analyze the first retrospective study to examine caffeine consumption and PD risk in a LRRK2 R1628P cohort.
Published Version: doi:10.1186/s40734-016-0037-8
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