Human papillomavirus infection in the oral cavity of HIV patients is not reduced by initiating antiretroviral therapy
View/ Open
Author
Shiboski, Caroline H.
Webster-Cyriaque, Jennifer
Seaman, Todd
Landovitz, Raphael J.
John, Malcolm
Reilly, Nancy
Naini, Linda
Palefsky, Joel
Jacobson, Mark A.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1097/QAD.0000000000001072Metadata
Show full item recordCitation
Shiboski, C. H., A. Lee, H. Chen, J. Webster-Cyriaque, T. Seaman, R. J. Landovitz, M. John, et al. 2016. “Human papillomavirus infection in the oral cavity of HIV patients is not reduced by initiating antiretroviral therapy.” AIDS (London, England) 30 (10): 1573-1582. doi:10.1097/QAD.0000000000001072. http://dx.doi.org/10.1097/QAD.0000000000001072.Abstract
Objective: The incidence of human papillomavirus (HPV)-related oral malignancies is increasing among HIV-infected populations, and the prevalence of oral warts has reportedly increased among HIV patients receiving antiretroviral therapy (ART). We explored whether ART initiation among treatment-naive HIV-positive adults is followed by a change in oral HPV infection or the occurrence of oral warts. Design: Prospective, observational study. Methods: HIV-1 infected, ART-naive adults initiating ART in a clinical trial were enrolled. End points included detection of HPV DNA in throat-washes, changes in CD4+ T-cell count and HIV RNA, and oral wart diagnosis. Results: Among 388 participants, 18% had at least one HPV genotype present before initiating ART, and 24% had at least one genotype present after 12–24 weeks of ART. Among those with undetectable oral HPV DNA before ART, median change in CD4+ count from study entry to 4 weeks after ART initiation was larger for those with detectable HPV DNA during follow-up than those without (P = 0.003). Both prevalence and incidence of oral warts were low (3% of participants having oral warts at study entry; 2.5% acquiring oral warts during 48 weeks of follow-up). Conclusion: These results suggest: effective immune control of HPV in the oral cavity of HIV-infected patients is not reconstituted by 24 weeks of ART; whereas ART initiation was not followed by an increase in oral warts, we observed an increase in oral HPV DNA detection after 12–24 weeks. The prevalence of HPV-associated oral malignancies may continue to increase in the modern ART era.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900420/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662242
Collections
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)