Biomineralization Guided by Paper Templates

DSpace/Manakin Repository

Biomineralization Guided by Paper Templates

Citable link to this page

 

 
Title: Biomineralization Guided by Paper Templates
Author: Camci-Unal, Gulden; Laromaine, Anna; Hong, Estrella; Derda, Ratmir; Whitesides, George M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Camci-Unal, Gulden, Anna Laromaine, Estrella Hong, Ratmir Derda, and George M. Whitesides. 2016. “Biomineralization Guided by Paper Templates.” Scientific Reports 6 (1): 27693. doi:10.1038/srep27693. http://dx.doi.org/10.1038/srep27693.
Full Text & Related Files:
Abstract: This work demonstrates the fabrication of partially mineralized scaffolds fabricated in 3D shapes using paper by folding, and by supporting deposition of calcium phosphate by osteoblasts cultured in these scaffolds. This process generates centimeter-scale free-standing structures composed of paper supporting regions of calcium phosphate deposited by osteoblasts. This work is the first demonstration that paper can be used as a scaffold to induce template-guided mineralization by osteoblasts. Because paper has a porous structure, it allows transport of O2 and nutrients across its entire thickness. Paper supports a uniform distribution of cells upon seeding in hydrogel matrices, and allows growth, remodelling, and proliferation of cells. Scaffolds made of paper make it possible to construct 3D tissue models easily by tuning material properties such as thickness, porosity, and density of chemical functional groups. Paper offers a new approach to study mechanisms of biomineralization, and perhaps ultimately new techniques to guide or accelerate the repair of bone.
Published Version: doi:10.1038/srep27693
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899756/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662265
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters