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dc.contributor.authorMachiela, Mitchell J.en_US
dc.contributor.authorZhou, Weiyinen_US
dc.contributor.authorKarlins, Ericen_US
dc.contributor.authorSampson, Joshua N.en_US
dc.contributor.authorFreedman, Neal D.en_US
dc.contributor.authorYang, Qien_US
dc.contributor.authorHicks, Belyndaen_US
dc.contributor.authorDagnall, Caseyen_US
dc.contributor.authorHautman, Christopheren_US
dc.contributor.authorJacobs, Kevin B.en_US
dc.contributor.authorAbnet, Christian C.en_US
dc.contributor.authorAldrich, Melinda C.en_US
dc.contributor.authorAmos, Christopheren_US
dc.contributor.authorAmundadottir, Laufey T.en_US
dc.contributor.authorArslan, Alan A.en_US
dc.contributor.authorBeane-Freeman, Laura E.en_US
dc.contributor.authorBerndt, Sonja I.en_US
dc.contributor.authorBlack, Amandaen_US
dc.contributor.authorBlot, William J.en_US
dc.contributor.authorBock, Cathryn H.en_US
dc.contributor.authorBracci, Paige M.en_US
dc.contributor.authorBrinton, Louise A.en_US
dc.contributor.authorBueno-de-Mesquita, H Basen_US
dc.contributor.authorBurdett, Laurieen_US
dc.contributor.authorBuring, Julie E.en_US
dc.contributor.authorButler, Mary A.en_US
dc.contributor.authorCanzian, Federicoen_US
dc.contributor.authorCarreón, Taniaen_US
dc.contributor.authorChaffee, Kari G.en_US
dc.contributor.authorChang, I-Shouen_US
dc.contributor.authorChatterjee, Nilanjanen_US
dc.contributor.authorChen, Chuen_US
dc.contributor.authorChen, Constanceen_US
dc.contributor.authorChen, Kexinen_US
dc.contributor.authorChung, Charles C.en_US
dc.contributor.authorCook, Linda S.en_US
dc.contributor.authorCrous Bou, Martaen_US
dc.contributor.authorCullen, Michaelen_US
dc.contributor.authorDavis, Faith G.en_US
dc.contributor.authorDe Vivo, Immaculataen_US
dc.contributor.authorDing, Tien_US
dc.contributor.authorDoherty, Jenniferen_US
dc.contributor.authorDuell, Eric J.en_US
dc.contributor.authorEpstein, Caroline G.en_US
dc.contributor.authorFan, Jin-Huen_US
dc.contributor.authorFigueroa, Jonine D.en_US
dc.contributor.authorFraumeni, Joseph F.en_US
dc.contributor.authorFriedenreich, Christine M.en_US
dc.contributor.authorFuchs, Charles S.en_US
dc.contributor.authorGallinger, Stevenen_US
dc.contributor.authorGao, Yu-Tangen_US
dc.contributor.authorGapstur, Susan M.en_US
dc.contributor.authorGarcia-Closas, Montserraten_US
dc.contributor.authorGaudet, Mia M.en_US
dc.contributor.authorGaziano, J. Michaelen_US
dc.contributor.authorGiles, Graham G.en_US
dc.contributor.authorGillanders, Elizabeth M.en_US
dc.contributor.authorGiovannucci, Edward L.en_US
dc.contributor.authorGoldin, Lynnen_US
dc.contributor.authorGoldstein, Alisa M.en_US
dc.contributor.authorHaiman, Christopher A.en_US
dc.contributor.authorHallmans, Goranen_US
dc.contributor.authorHankinson, Susan E.en_US
dc.contributor.authorHarris, Curtis C.en_US
dc.contributor.authorHenriksson, Rogeren_US
dc.contributor.authorHolly, Elizabeth A.en_US
dc.contributor.authorHong, Yun-Chulen_US
dc.contributor.authorHoover, Robert N.en_US
dc.contributor.authorHsiung, Chao A.en_US
dc.contributor.authorHu, Nanen_US
dc.contributor.authorHu, Weien_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorHutchinson, Amyen_US
dc.contributor.authorJenab, Mazdaen_US
dc.contributor.authorJohansen, Christofferen_US
dc.contributor.authorKhaw, Kay-Teeen_US
dc.contributor.authorKim, Hee Namen_US
dc.contributor.authorKim, Yeul Hongen_US
dc.contributor.authorKim, Young Taeen_US
dc.contributor.authorKlein, Alison P.en_US
dc.contributor.authorKlein, Roberten_US
dc.contributor.authorKoh, Woon-Puayen_US
dc.contributor.authorKolonel, Laurence N.en_US
dc.contributor.authorKooperberg, Charlesen_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorKrogh, Vittorioen_US
dc.contributor.authorKurtz, Robert C.en_US
dc.contributor.authorLaCroix, Andreaen_US
dc.contributor.authorLan, Qingen_US
dc.contributor.authorLandi, Maria Teresaen_US
dc.contributor.authorMarchand, Loic Leen_US
dc.contributor.authorLi, Donghuien_US
dc.contributor.authorLiang, Xiaolinen_US
dc.contributor.authorLiao, Linda M.en_US
dc.contributor.authorLin, Dongxinen_US
dc.contributor.authorLiu, Jianjunen_US
dc.contributor.authorLissowska, Jolantaen_US
dc.contributor.authorLu, Lingengen_US
dc.contributor.authorMagliocco, Anthony M.en_US
dc.contributor.authorMalats, Nuriaen_US
dc.contributor.authorMatsuo, Keitaroen_US
dc.contributor.authorMcNeill, Lorna H.en_US
dc.contributor.authorMcWilliams, Robert R.en_US
dc.contributor.authorMelin, Beatrice S.en_US
dc.contributor.authorMirabello, Lisaen_US
dc.contributor.authorMoore, Leeen_US
dc.contributor.authorOlson, Sara H.en_US
dc.contributor.authorOrlow, Ireneen_US
dc.contributor.authorPark, Jae Yongen_US
dc.contributor.authorPatiño-Garcia, Anaen_US
dc.contributor.authorPeplonska, Beataen_US
dc.contributor.authorPeters, Ulrikeen_US
dc.contributor.authorPetersen, Gloria M.en_US
dc.contributor.authorPooler, Loreallen_US
dc.contributor.authorPrescott, Jenniferen_US
dc.contributor.authorProkunina-Olsson, Ludmilaen_US
dc.contributor.authorPurdue, Mark P.en_US
dc.contributor.authorQiao, You-Linen_US
dc.contributor.authorRajaraman, Preethaen_US
dc.contributor.authorReal, Francisco X.en_US
dc.contributor.authorRiboli, Elioen_US
dc.contributor.authorRisch, Harvey A.en_US
dc.contributor.authorRodriguez-Santiago, Benjaminen_US
dc.contributor.authorRuder, Avima M.en_US
dc.contributor.authorSavage, Sharon A.en_US
dc.contributor.authorSchumacher, Fredricken_US
dc.contributor.authorSchwartz, Ann G.en_US
dc.contributor.authorSchwartz, Kendra L.en_US
dc.contributor.authorSeow, Adelineen_US
dc.contributor.authorWendy Setiawan, Veronicaen_US
dc.contributor.authorSeveri, Gianlucaen_US
dc.contributor.authorShen, Hongbingen_US
dc.contributor.authorSheng, Xinen_US
dc.contributor.authorShin, Min-Hoen_US
dc.contributor.authorShu, Xiao-Ouen_US
dc.contributor.authorSilverman, Debra T.en_US
dc.contributor.authorSpitz, Margaret R.en_US
dc.contributor.authorStevens, Victoria L.en_US
dc.contributor.authorStolzenberg-Solomon, Rachaelen_US
dc.contributor.authorStram, Danielen_US
dc.contributor.authorTang, Ze-Zhongen_US
dc.contributor.authorTaylor, Philip R.en_US
dc.contributor.authorTeras, Lauren R.en_US
dc.contributor.authorTobias, Geoffrey S.en_US
dc.contributor.authorVan Den Berg, Daviden_US
dc.contributor.authorVisvanathan, Kalaen_US
dc.contributor.authorWacholder, Sholomen_US
dc.contributor.authorWang, Jiu-Cunen_US
dc.contributor.authorWang, Zhaomingen_US
dc.contributor.authorWentzensen, Nicolasen_US
dc.contributor.authorWheeler, Williamen_US
dc.contributor.authorWhite, Emilyen_US
dc.contributor.authorWiencke, John K.en_US
dc.contributor.authorWolpin, Brian M.en_US
dc.contributor.authorWong, Maria Piken_US
dc.contributor.authorWu, Chenen_US
dc.contributor.authorWu, Tangchunen_US
dc.contributor.authorWu, Xifengen_US
dc.contributor.authorWu, Yi-Longen_US
dc.contributor.authorWunder, Jay S.en_US
dc.contributor.authorXia, Lucyen_US
dc.contributor.authorYang, Hannah P.en_US
dc.contributor.authorYang, Pan-Chyren_US
dc.contributor.authorYu, Kaien_US
dc.contributor.authorZanetti, Krista A.en_US
dc.contributor.authorZeleniuch-Jacquotte, Anneen_US
dc.contributor.authorZheng, Weien_US
dc.contributor.authorZhou, Baosenen_US
dc.contributor.authorZiegler, Regina G.en_US
dc.contributor.authorPerez-Jurado, Luis A.en_US
dc.contributor.authorCaporaso, Neil E.en_US
dc.contributor.authorRothman, Nathanielen_US
dc.contributor.authorTucker, Margareten_US
dc.contributor.authorDean, Michael C.en_US
dc.contributor.authorYeager, Meredithen_US
dc.contributor.authorChanock, Stephen J.en_US
dc.date.accessioned2016-07-14T19:19:38Z
dc.date.issued2016en_US
dc.identifier.citationMachiela, M. J., W. Zhou, E. Karlins, J. N. Sampson, N. D. Freedman, Q. Yang, B. Hicks, et al. 2016. “Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.” Nature Communications 7 (1): 11843. doi:10.1038/ncomms11843. http://dx.doi.org/10.1038/ncomms11843.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27662285
dc.description.abstractTo investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/ncomms11843en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909985/pdf/en
dash.licenseLAAen_US
dc.titleFemale chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosomeen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorCrous Bou, Martaen_US
dc.date.available2016-07-14T19:19:38Z
dc.identifier.doi10.1038/ncomms11843*
dash.authorsorderedfalse
dash.contributor.affiliatedCrous Bou, Marta
dash.contributor.affiliatedDe Vivo, Immaculata
dash.contributor.affiliatedFuchs, Charles
dash.contributor.affiliatedHankinson, Susan
dash.contributor.affiliatedGaziano, John
dash.contributor.affiliatedGiovannucci, Edward
dash.contributor.affiliatedKraft, Phillip
dash.contributor.affiliatedHunter, David


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