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dc.contributor.authorGarza, Jennifer L.en_US
dc.contributor.authorMittleman, Murray A.en_US
dc.contributor.authorZhang, Jinmingen_US
dc.contributor.authorChristiani, David C.en_US
dc.contributor.authorCavallari, Jennifer Men_US
dc.date.accessioned2016-07-14T19:20:16Z
dc.date.issued2016en_US
dc.identifier.citationGarza, Jennifer L., Murray A. Mittleman, Jinming Zhang, David C. Christiani, and Jennifer M Cavallari. 2016. “Time Course of Heart Rate Variability Response to PM2.5 Exposure from Secondhand Smoke.” PLoS ONE 11 (5): e0154783. doi:10.1371/journal.pone.0154783. http://dx.doi.org/10.1371/journal.pone.0154783.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27662307
dc.description.abstractPurpose: Exposure to secondhand smoke (SHS) has been associated with decreased heart rate variability (HRV). However, the time course of this association is unclear. Therefore, the objective of this study was to investigate the association between 15–240 minute SHS-related fine particulate matter (PM2.5) moving averages and indices of HRV. Methods: With a panel study design, we used personal monitors to continuously measure PM2.5 and HRV of 35 participants who were exposed to SHS for approximately 6 hours. Results: We observed negative, significant associations between 5-minute HRV indices and 15 minute PM2.5 moving averages and 240 minute PM2.5 moving averages: there was a significant (p<0.01) 7.5% decrease in the 5-minute square root of the mean squared differences of successive normal heart beats associated with (RMSSD), and a significant (p<0.01) 14.7% decrease in the 5-minute high frequency (HF) power associated with the 15 minute PM2.5 moving averages; there was also a significant (p<0.01) 46.9% decrease in the 5-minute RMSSD, and a significant (p<0.01) 77.7% decrease in the 5-minute high frequency (HF) power associated with the 240 minute PM2.5 moving averages. Conclusions: Our findings that exposure to SHS related PM2.5 was associated with HRV support the hypothesis that SHS can affect the cardiovascular system. The negative associations reported between short and longer term PM2.5 and HRV indicate adverse effects of SHS on the cardiovascular system.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0154783en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880193/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectPharmacologyen
dc.subjectDrugsen
dc.subjectStatinsen
dc.subjectCardiologyen
dc.subjectHeart Rateen
dc.subjectBioassays and Physiological Analysisen
dc.subjectElectrophysiological Techniquesen
dc.subjectCardiac Electrophysiologyen
dc.subjectElectrocardiographyen
dc.subjectEngineering and Technologyen
dc.subjectEnvironmental Engineeringen
dc.subjectPollutionen
dc.subjectAir Pollutionen
dc.subjectPhysical Sciencesen
dc.subjectMaterials Scienceen
dc.subjectMaterials by Structureen
dc.subjectMixturesen
dc.subjectParticulatesen
dc.subjectHealth Careen
dc.subjectHealth Risk Analysisen
dc.subjectBiology and Life Sciencesen
dc.subjectAnatomyen
dc.subjectNervous Systemen
dc.subjectAutonomic Nervous Systemen
dc.subjectPhysiologyen
dc.subjectPhysiological Parametersen
dc.subjectBody Weighten
dc.subjectBody Mass Indexen
dc.titleTime Course of Heart Rate Variability Response to PM2.5 Exposure from Secondhand Smokeen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorMittleman, Murray A.en_US
dc.date.available2016-07-14T19:20:16Z
dc.identifier.doi10.1371/journal.pone.0154783*
dash.contributor.affiliatedCavallari, Jennifer M
dash.contributor.affiliatedMittleman, Murray
dash.contributor.affiliatedChristiani, David


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