In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography

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In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography

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Title: In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography
Author: Blatter, Cedric; Meijer, Eelco F. J.; Nam, Ahhyun S.; Jones, Dennis; Bouma, Brett E.; Padera, Timothy P.; Vakoc, Benjamin J.

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Citation: Blatter, Cedric, Eelco F. J. Meijer, Ahhyun S. Nam, Dennis Jones, Brett E. Bouma, Timothy P. Padera, and Benjamin J. Vakoc. 2016. “In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography.” Scientific Reports 6 (1): 29035. doi:10.1038/srep29035. http://dx.doi.org/10.1038/srep29035.
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Abstract: Direct in vivo imaging of lymph flow is key to understanding lymphatic system function in normal and disease states. Optical microscopy techniques provide the resolution required for these measurements, but existing optical techniques for measuring lymph flow require complex protocols and provide limited temporal resolution. Here, we describe a Doppler optical coherence tomography platform that allows direct, label-free quantification of lymph velocity and volumetric flow rates. We overcome the challenge of very low scattering by employing a Doppler algorithm that operates on low signal-to-noise measurements. We show that this technique can measure lymph velocity at sufficiently high temporal resolution to resolve the dynamic pulsatile flow in collecting lymphatic vessels.
Published Version: doi:10.1038/srep29035
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932526/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822084
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