Relations of Central Hemodynamics and Aortic Stiffness with Left Ventricular Structure and Function: The Framingham Heart Study
View/ Open
Author
Kaess, Bernhard M.
Rong, Jian
Larson, Martin G.
Hamburg, Naomi M.
Vita, Joseph A.
Aragam, Jayashree
Levy, Daniel
Benjamin, Emelia J.
Vasan, Ramachandran S.
Mitchell, Gary F.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1161/JAHA.115.002693Metadata
Show full item recordCitation
Kaess, B. M., J. Rong, M. G. Larson, N. M. Hamburg, J. A. Vita, S. Cheng, J. Aragam, et al. 2016. “Relations of Central Hemodynamics and Aortic Stiffness with Left Ventricular Structure and Function: The Framingham Heart Study.” Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 5 (3): e002693. doi:10.1161/JAHA.115.002693. http://dx.doi.org/10.1161/JAHA.115.002693.Abstract
Background: The differing relations of steady and pulsatile components of central hemodynamics and aortic stiffness with cardiac dimensions and function have not been fully elucidated. Methods and Results: Central hemodynamics and carotid‐femoral pulse wave velocity (CFPWV, a measure of aortic stiffness) were measured by arterial tonometry in 5799 participants of the Framingham Heart Study (mean age 51 years, 54% women) and related to echocardiographic left ventricular (LV) dimensions and systolic and diastolic function using multivariable‐adjusted partial Pearson correlations. Mean arterial pressure (MAP, steady component of central blood pressure) was associated positively with LV wall thickness (r=0.168; P<0.0001) but showed only a weak direct association with LV diastolic dimension (r=0.035, P=0.006). Central pulse pressure (pulsatile component of central blood pressure) showed a direct correlation with both LV diastolic dimension and LV wall thickness (r=0.08 and 0.044, both P<0.0001 in multivariable models that included MAP). CFPWV was not associated with LV structure (all P≥0.27) in MAP‐adjusted models). Both MAP and CFPWV were associated inversely with LV diastolic function (E′; r=−0.140 and −0.153, respectively; both P<0.0001), and these associations persisted after additional adjustment for LV mass and central pulse pressure (r=−0.142 and −0.108, both P<0.0001). MAP and CFPWV were not associated with LV fractional shortening (P≥0.10), whereas central pulse pressure was positively related (r=0.064, P<0.0001). Conclusions: Pulsatile and steady components of central pressure are conjointly yet variably related to LV structure. CFPWV is related to LV diastolic function but not to systolic function. Additional studies are warranted to confirm these observations.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943246/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822167
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)