Genesis and growth of extracellular vesicle-derived microcalcification in atherosclerotic plaques

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Genesis and growth of extracellular vesicle-derived microcalcification in atherosclerotic plaques

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Title: Genesis and growth of extracellular vesicle-derived microcalcification in atherosclerotic plaques
Author: Hutcheson, Joshua D.; Goettsch, Claudia; Bertazzo, Sergio; Maldonado, Natalia; Ruiz, Jessica L.; Goh, Wilson; Yabusaki, Katsumi; Faits, Tyler; Bouten, Carlijn; Franck, Gregory; Quillard, Thibaut; Libby, Peter; Aikawa, Masanori; Weinbaum, Sheldon; Aikawa, Elena

Note: Order does not necessarily reflect citation order of authors.

Citation: Hutcheson, J. D., C. Goettsch, S. Bertazzo, N. Maldonado, J. L. Ruiz, W. Goh, K. Yabusaki, et al. 2015. “Genesis and growth of extracellular vesicle-derived microcalcification in atherosclerotic plaques.” Nature materials 15 (3): 335-343. doi:10.1038/nmat4519. http://dx.doi.org/10.1038/nmat4519.
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Abstract: Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of the stress distribution within atherosclerotic plaques has suggested that subcellular microcalcifications in the fibrous cap may promote material failure of the plaque, but that large calcifications can stabilize it. Yet the physicochemical mechanisms underlying such mineral formation and growth in atheromata remain unknown. Here, by using three-dimensional collagen hydrogels that mimic structural features of the atherosclerotic fibrous cap, and high-resolution microscopic and spectroscopic analyses of both the hydrogels and of calcified human plaques, we demonstrate that calcific mineral formation and maturation results from a series of events involving the aggregation of calcifying extracellular vesicles, and the formation of microcalcifications and ultimately large calcification zones. We also show that calcification morphology and the plaque’s collagen content – two determinants of atherosclerotic plaque stability - are interlinked.
Published Version: doi:10.1038/nmat4519
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767675/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822182
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