Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications
Sohani, Aliyah R.
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CitationPathania, D., H. Im, A. Kilcoyne, A. R. Sohani, L. Fexon, M. Pivovarov, J. S. Abramson, et al. 2016. “Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications.” Theranostics 6 (10): 1603-1610. doi:10.7150/thno.15534. http://dx.doi.org/10.7150/thno.15534.
AbstractLow-cost, rapid and accurate detection technologies are key requisites to cope with the growing global cancer challenges. The need is particularly pronounced in resource-limited settings where treatment opportunities are often missed due to the absence of timely diagnoses. We herein describe a Holographic Assessment of Lymphoma Tissue (HALT) system that adopts a smartphone as the basis for molecular cancer diagnostics. The system detects malignant lymphoma cells labeled with marker-specific microbeads that produce unique holographic signatures. Importantly, we optimized HALT to detect lymphomas in fine-needle aspirates from superficial lymph nodes, procedures that align with the minimally invasive biopsy needs of resource-constrained regions. We equipped the platform to directly address the practical needs of employing novel technologies for “real world” use. The HALT assay generated readouts in <1.5 h and demonstrated good agreement with standard cytology and surgical pathology.
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