The Role of Autophagy-Related Proteins in Candida albicans Infections

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The Role of Autophagy-Related Proteins in Candida albicans Infections

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Title: The Role of Autophagy-Related Proteins in Candida albicans Infections
Author: Tam, Jenny M.; Mansour, Michael K.; Acharya, Mridu; Sokolovska, Anna; Timmons, Allison K.; Lacy-Hulbert, Adam; Vyas, Jatin M.

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Citation: Tam, Jenny M., Michael K. Mansour, Mridu Acharya, Anna Sokolovska, Allison K. Timmons, Adam Lacy-Hulbert, and Jatin M. Vyas. 2016. “The Role of Autophagy-Related Proteins in Candida albicans Infections.” Pathogens 5 (2): 34. doi:10.3390/pathogens5020034. http://dx.doi.org/10.3390/pathogens5020034.
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Abstract: Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autophagosomes. Recently, a role for LC3 in the elimination of pathogenic bacteria and fungi, including Candida albicans (C. albicans), was demonstrated, but these organisms reside in single membrane phagosomes. This process is distinct from autophagy and is termed LC3-associated phagocytosis (LAP). This review will detail the hallmarks of LAP that distinguish it from classical autophagy and review the role of autophagy proteins in host response to C. albicans and other pathogenic fungi.
Published Version: doi:10.3390/pathogens5020034
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931385/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822234
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