Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

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Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

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Title: Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair
Author: Barreiro, Olga; Cibrian, Danay; Clemente, Cristina; Alvarez, David; Moreno, Vanessa; Valiente, Íñigo; Bernad, Antonio; Vestweber, Dietmar; Arroyo, Alicia G; Martín, Pilar; von Andrian, Ulrich H; Sánchez Madrid, Francisco

Note: Order does not necessarily reflect citation order of authors.

Citation: Barreiro, O., D. Cibrian, C. Clemente, D. Alvarez, V. Moreno, Í. Valiente, A. Bernad, et al. 2016. “Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair.” eLife 5 (1): e15251. doi:10.7554/eLife.15251. http://dx.doi.org/10.7554/eLife.15251.
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Abstract: Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1+ progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis. DOI: http://dx.doi.org/10.7554/eLife.15251.001
Published Version: doi:10.7554/eLife.15251
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961461/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822237
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