A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

DSpace/Manakin Repository

A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

Citable link to this page

 

 
Title: A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells
Author: Skoge, Monica; Wong, Elisabeth; Hamza, Bashar; Bae, Albert; Martel, Joseph; Kataria, Rama; Keizer-Gunnink, Ineke; Kortholt, Arjan; Van Haastert, Peter J. M.; Charras, Guillaume; Janetopoulos, Christopher; Irimia, Daniel

Note: Order does not necessarily reflect citation order of authors.

Citation: Skoge, M., E. Wong, B. Hamza, A. Bae, J. Martel, R. Kataria, I. Keizer-Gunnink, et al. 2016. “A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells.” PLoS ONE 11 (6): e0154491. doi:10.1371/journal.pone.0154491. http://dx.doi.org/10.1371/journal.pone.0154491.
Full Text & Related Files:
Abstract: Chemotaxis is the ability to migrate towards the source of chemical gradients. It underlies the ability of neutrophils and other immune cells to hone in on their targets and defend against invading pathogens. Given the importance of neutrophil migration to health and disease, it is crucial to understand the basic mechanisms controlling chemotaxis so that strategies can be developed to modulate cell migration in clinical settings. Because of the complexity of human genetics, Dictyostelium and HL60 cells have long served as models system for studying chemotaxis. Since many of our current insights into chemotaxis have been gained from these two model systems, we decided to compare them side by side in a set of winner-take-all races, the Dicty World Races. These worldwide competitions challenge researchers to genetically engineer and pharmacologically enhance the model systems to compete in microfluidic racecourses. These races bring together technological innovations in genetic engineering and precision measurement of cell motility. Fourteen teams participated in the inaugural Dicty World Race 2014 and contributed cell lines, which they tuned for enhanced speed and chemotactic accuracy. The race enabled large-scale analyses of chemotaxis in complex environments and revealed an intriguing balance of speed and accuracy of the model cell lines. The successes of the first race validated the concept of using fun-spirited competition to gain insights into the complex mechanisms controlling chemotaxis, while the challenges of the first race will guide further technological development and planning of future events.
Published Version: doi:10.1371/journal.pone.0154491
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917115/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822272
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters