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dc.contributor.authorGelaye, Bizuen_US
dc.contributor.authorSumner, Susan J.en_US
dc.contributor.authorMcRitchie, Susanen_US
dc.contributor.authorCarlson, James E.en_US
dc.contributor.authorAnanth, Cande V.en_US
dc.contributor.authorEnquobahrie, Daniel A.en_US
dc.contributor.authorQiu, Chunfangen_US
dc.contributor.authorSorensen, Tanya K.en_US
dc.contributor.authorWilliams, Michelle A.en_US
dc.date.accessioned2016-08-09T14:53:42Z
dc.date.issued2016en_US
dc.identifier.citationGelaye, Bizu, Susan J. Sumner, Susan McRitchie, James E. Carlson, Cande V. Ananth, Daniel A. Enquobahrie, Chunfang Qiu, Tanya K. Sorensen, and Michelle A. Williams. 2016. “Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study.” PLoS ONE 11 (6): e0156755. doi:10.1371/journal.pone.0156755. http://dx.doi.org/10.1371/journal.pone.0156755.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27822308
dc.description.abstractBackground & Objective Placental abruption, an ischemic placental disorder, complicates about 1 in 100 pregnancies, and is an important cause of maternal and perinatal morbidity and mortality worldwide. Metabolomics holds promise for improving the phenotyping, prediction and understanding of pathophysiologic mechanisms of complex clinical disorders including abruption. We sought to evaluate maternal early pregnancy pre-diagnostic serum metabolic profiles and abnormal vaginal bleeding as predictors of abruption later in pregnancy. Methods: Maternal serum was collected in early pregnancy (mean 16 weeks, range 15 to 22 weeks) from 51 abruption cases and 51 controls. Quantitative targeted metabolic profiles of serum were acquired using electrospray ionization liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and the Absolute IDQ® p180 kit. Maternal sociodemographic characteristics and reproductive history were abstracted from medical records. Stepwise logistic regression models were developed to evaluate the extent to which metabolites aid in the prediction of abruption. We evaluated the predictive performance of the set of selected metabolites using a receiver operating characteristics (ROC) curve analysis and area under the curve (AUC). Results: Early pregnancy vaginal bleeding, dodecanoylcarnitine/dodecenoylcarnitine (C12 / C12:1), and phosphatidylcholine acyl-alkyl C 38:1 (PC ae C38:1) strongly predict abruption risk. The AUC for these metabolites alone was 0.68, for early pregnancy vaginal bleeding alone was 0.65, and combined the AUC improved to 0.75 with the addition of quantitative metabolite data (P = 0.003). Conclusion: Metabolomic profiles of early pregnancy maternal serum samples in addition to the clinical symptom, vaginal bleeding, may serve as important markers for the prediction of abruption. Larger studies are necessary to corroborate and validate these findings in other cohorts.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0156755en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907440/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectWomen's Healthen
dc.subjectMaternal Healthen
dc.subjectPregnancyen
dc.subjectObstetrics and Gynecologyen
dc.subjectDiagnostic Medicineen
dc.subjectSigns and Symptomsen
dc.subjectHemorrhageen
dc.subjectPathology and Laboratory Medicineen
dc.subjectVascular Medicineen
dc.subjectBiology and Life Sciencesen
dc.subjectBiochemistryen
dc.subjectMetabolismen
dc.subjectMetabolitesen
dc.subjectMetabolomicsen
dc.subjectBlood Pressureen
dc.subjectHypertensionen
dc.subjectHypertensive Disorders in Pregnancyen
dc.subjectBioenergeticsen
dc.subjectEnergy-Producing Organellesen
dc.subjectMitochondriaen
dc.subjectCell Biologyen
dc.subjectCellular Structures and Organellesen
dc.subjectPharmacologyen
dc.subjectPharmacokineticsen
dc.subjectDrug Metabolismen
dc.subjectMetabolic Disordersen
dc.titleMaternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorGelaye, Bizuen_US
dc.date.available2016-08-09T14:53:42Z
dc.identifier.doi10.1371/journal.pone.0156755*
dash.contributor.affiliatedGelaye, Bizu
dash.contributor.affiliatedWilliams, Michelle
dc.identifier.orcid0000-0001-5807-5281


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