Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study

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Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study

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dc.contributor.author Nwanaji-Enwerem, Jamaji C. en_US
dc.contributor.author Colicino, Elena en_US
dc.contributor.author Trevisi, Letizia en_US
dc.contributor.author Kloog, Itai en_US
dc.contributor.author Just, Allan C. en_US
dc.contributor.author Shen, Jincheng en_US
dc.contributor.author Brennan, Kasey en_US
dc.contributor.author Dereix, Alexandra en_US
dc.contributor.author Hou, Lifang en_US
dc.contributor.author Vokonas, Pantel en_US
dc.contributor.author Schwartz, Joel en_US
dc.contributor.author Baccarelli, Andrea A. en_US
dc.date.accessioned 2016-08-09T14:53:55Z
dc.date.issued 2016 en_US
dc.identifier.citation Nwanaji-Enwerem, J. C., E. Colicino, L. Trevisi, I. Kloog, A. C. Just, J. Shen, K. Brennan, et al. 2016. “Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study.” Environmental epigenetics 2 (2): dvw006. doi:10.1093/eep/dvw006. http://dx.doi.org/10.1093/eep/dvw006. en
dc.identifier.issn 2058-5888 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:27822325
dc.description.abstract Background: Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies have examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide DNA methylation based predictor of chronological age. Objective: We examined the relationship of DNAm-age with fine particulate matter (PM2.5), a measure of total inhalable particle mass, and black carbon (BC), a measure of particles from vehicular traffic. Methods: We used validated spatiotemporal models to generate 1-year PM2.5 and BC exposure levels at the addresses of 589 older men participating in the VA Normative Aging Study with 1–3 visits between 2000 and 2011 (n = 1032 observations). Blood DNAm-age was calculated using 353 CpG sites from the Illumina HumanMethylation450 BeadChip. We estimated associations of PM2.5 and BC with DNAm-age using linear mixed effects models adjusted for age, lifestyle/environmental factors, and aging-related diseases. Results: After adjusting for covariates, a 1-µg/m3 increase in PM2.5 (95% CI: 0.30, 0.75, P<0.0001) was significantly associated with a 0.52-year increase in DNAm-age. Adjusted BC models showed similar patterns of association (β = 3.02, 95% CI: 0.48, 5.57, P = 0.02). Only PM2.5 (β = 0.54, 95% CI: 0.24, 0.84, P = 0.0004) remained significantly associated with DNAm-age in two-particle models. Methylation levels from 20 of the 353 CpGs contributing to DNAm-age were significantly associated with PM2.5 levels in our two-particle models. Several of these CpGs mapped to genes implicated in lung pathologies including LZTFL1, PDLIM5, and ATPAF1. Conclusion: Our results support an association of long-termambient particle levels with DNAm-age and suggest that DNAm-age is a biomarker of particle-related physiological processes. en
dc.language.iso en_US en
dc.relation.isversionof doi:10.1093/eep/dvw006 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957520/pdf/ en
dash.license LAA en_US
dc.subject Epigenetics en
dc.subject DNA methylation age en
dc.subject particulate matter 2.5 en
dc.subject black carbon en
dc.title Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Environmental epigenetics en
dash.depositing.author Nwanaji-Enwerem, Jamaji C. en_US
dc.date.available 2016-08-09T14:53:55Z

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