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dc.contributor.authorNwanaji-Enwerem, Jamaji C.en_US
dc.contributor.authorColicino, Elenaen_US
dc.contributor.authorTrevisi, Letiziaen_US
dc.contributor.authorKloog, Itaien_US
dc.contributor.authorJust, Allan C.en_US
dc.contributor.authorShen, Jinchengen_US
dc.contributor.authorBrennan, Kaseyen_US
dc.contributor.authorDereix, Alexandraen_US
dc.contributor.authorHou, Lifangen_US
dc.contributor.authorVokonas, Pantelen_US
dc.contributor.authorSchwartz, Joelen_US
dc.contributor.authorBaccarelli, Andrea A.en_US
dc.date.accessioned2016-08-09T14:53:55Z
dc.date.issued2016en_US
dc.identifier.citationNwanaji-Enwerem, J. C., E. Colicino, L. Trevisi, I. Kloog, A. C. Just, J. Shen, K. Brennan, et al. 2016. “Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study.” Environmental epigenetics 2 (2): dvw006. doi:10.1093/eep/dvw006. http://dx.doi.org/10.1093/eep/dvw006.en
dc.identifier.issn2058-5888en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27822325
dc.description.abstractBackground: Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies have examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide DNA methylation based predictor of chronological age. Objective: We examined the relationship of DNAm-age with fine particulate matter (PM2.5), a measure of total inhalable particle mass, and black carbon (BC), a measure of particles from vehicular traffic. Methods: We used validated spatiotemporal models to generate 1-year PM2.5 and BC exposure levels at the addresses of 589 older men participating in the VA Normative Aging Study with 1–3 visits between 2000 and 2011 (n = 1032 observations). Blood DNAm-age was calculated using 353 CpG sites from the Illumina HumanMethylation450 BeadChip. We estimated associations of PM2.5 and BC with DNAm-age using linear mixed effects models adjusted for age, lifestyle/environmental factors, and aging-related diseases. Results: After adjusting for covariates, a 1-µg/m3 increase in PM2.5 (95% CI: 0.30, 0.75, P<0.0001) was significantly associated with a 0.52-year increase in DNAm-age. Adjusted BC models showed similar patterns of association (β = 3.02, 95% CI: 0.48, 5.57, P = 0.02). Only PM2.5 (β = 0.54, 95% CI: 0.24, 0.84, P = 0.0004) remained significantly associated with DNAm-age in two-particle models. Methylation levels from 20 of the 353 CpGs contributing to DNAm-age were significantly associated with PM2.5 levels in our two-particle models. Several of these CpGs mapped to genes implicated in lung pathologies including LZTFL1, PDLIM5, and ATPAF1. Conclusion: Our results support an association of long-termambient particle levels with DNAm-age and suggest that DNAm-age is a biomarker of particle-related physiological processes.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1093/eep/dvw006en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957520/pdf/en
dash.licenseLAAen_US
dc.subjectEpigeneticsen
dc.subjectDNA methylation ageen
dc.subjectparticulate matter 2.5en
dc.subjectblack carbonen
dc.titleLong-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEnvironmental epigeneticsen
dash.depositing.authorNwanaji-Enwerem, Jamaji C.en_US
dc.date.available2016-08-09T14:53:55Z
dc.identifier.doi10.1093/eep/dvw006*
dash.authorsorderedfalse
dash.contributor.affiliatedShen, Jincheng
dash.contributor.affiliatedNwanaji-Enwerem, Jamaji
dash.contributor.affiliatedTrevisi, Letizia
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedBaccarelli, Andrea


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