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dc.contributor.authorBerck, Matthew Een_US
dc.contributor.authorKhandelwal, Avinashen_US
dc.contributor.authorClaus, Lindseyen_US
dc.contributor.authorHernandez-Nunez, Luisen_US
dc.contributor.authorSi, Guangweien_US
dc.contributor.authorTabone, Christopher Jen_US
dc.contributor.authorLi, Fengen_US
dc.contributor.authorTruman, James Wen_US
dc.contributor.authorFetter, Rick Den_US
dc.contributor.authorLouis, Matthieuen_US
dc.contributor.authorSamuel, Aravinthan DTen_US
dc.contributor.authorCardona, Alberten_US
dc.date.accessioned2016-08-09T14:54:03Z
dc.date.issued2016en_US
dc.identifier.citationBerck, M. E., A. Khandelwal, L. Claus, L. Hernandez-Nunez, G. Si, C. J. Tabone, F. Li, et al. 2016. “The wiring diagram of a glomerular olfactory system.” eLife 5 (1): e14859. doi:10.7554/eLife.14859. http://dx.doi.org/10.7554/eLife.14859.en
dc.identifier.issn2050-084Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:27822331
dc.description.abstractThe sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity to the mushroom body and the lateral horn. A second, parallel circuit with multiglomerular projection neurons (mPNs) and hierarchically connected local neurons (LNs) selectively integrates multiple ORN signals already at the first synapse. LN-LN synaptic connections putatively implement a bistable gain control mechanism that either computes odor saliency through panglomerular inhibition, or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odors. This complete wiring diagram will support experimental and theoretical studies towards bridging the gap between circuits and behavior. DOI: http://dx.doi.org/10.7554/eLife.14859.001en
dc.language.isoen_USen
dc.publishereLife Sciences Publications, Ltden
dc.relation.isversionofdoi:10.7554/eLife.14859en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930330/pdf/en
dash.licenseLAAen_US
dc.subjectolfactionen
dc.subjectneural circuitsen
dc.subjecten
dc.subjectelectron microscopyen
dc.subjectconnectomicsen
dc.titleThe wiring diagram of a glomerular olfactory systemen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journaleLifeen
dash.depositing.authorBerck, Matthew Een_US
dc.date.available2016-08-09T14:54:03Z
dc.identifier.doi10.7554/eLife.14859*
dash.authorsorderedfalse
dash.contributor.affiliatedSi, Guangwei
dash.contributor.affiliatedTabone, Christopher
dash.contributor.affiliatedBerck, Matthew
dash.contributor.affiliatedSamuel, Aravinthan


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