Show simple item record

dc.contributor.authorNiznikiewicz, Margaret A.
dc.contributor.authorDonnino, Robert
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorNestor, Paul Gerard
dc.contributor.authorIosifescu, Daniel V.
dc.contributor.authorO'Donnell, Brian
dc.contributor.authorLevitt, James Jonathan
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-14T19:53:12Z
dc.date.issued2000
dc.identifier.citationNiznikiewicz, M. 2000. “Abnormal Angular Gyrus Asymmetry in Schizophrenia.” American Journal of Psychiatry 157 (3) (March 1): 428–437. doi:10.1176/appi.ajp.157.3.428.en_US
dc.identifier.issn0002-953Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28501484
dc.description.abstractObjective: Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language—all functions that have been reported to be abnormal in schizophrenia. The inferior parietal lobule, in particular, is of interest because it is not only part of the heteromodal association cortex but also is part of the semantic-lexical network, which also includes the planum temporale. Both the inferior parietal lobule, particularly the angular gyrus of the inferior parietal lobule, and the planum temporale are brain regions that play a critical role as biological substrates of language and thought. The authors compared volume and asymmetry measures of the individual gyri of the parietal lobe by means of magnetic resonance imaging (MRI) scans. Method: MRI scans with a 1.5-Tesla magnet were obtained from 15 male chronic schizophrenic and 15 comparison subjects matched for age, gender, and parental socioeconomic status. Results: Inferior parietal lobule volumes showed a leftward asymmetry (left 7.0% larger than right) in comparison subjects and a reversed asymmetry (left 6.3% smaller than right) in schizophrenic subjects. The angular gyrus accounted for this difference in asymmetry, with the left angular gyrus being significantly larger (18.7%) than the right in comparison subjects, a finding that was not observed in schizophrenic patients. A further test of angular gyrus asymmetry showed a reversal of the normal left-greater-than-right asymmetry in the schizophrenic patients. Conclusions: Patients with schizophrenia showed a reversed asymmetry in the inferior parietal lobule that was localized to the angular gyrus, a structure belonging to the heteromodal association cortex as well as being part of the semantic-lexical network. This finding contributes to a more comprehensive understanding of the neural substrates of language and thought disorder in schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Psychiatric Publishingen_US
dc.relation.isversionofdoi:10.1176/appi.ajp.157.3.428en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846293/en_US
dash.licenseLAA
dc.titleAbnormal Angular Gyrus Asymmetry in Schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalAmerican Journal of Psychiatryen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-14T19:53:12Z
dc.identifier.doi10.1176/appi.ajp.157.3.428*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedLevitt, James
dash.contributor.affiliatedNestor, Paul
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedNiznikiewicz, Margaret
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0003-3191-2005


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record