Lateralized P3 deficit in schizotypal personality disorder

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Lateralized P3 deficit in schizotypal personality disorder

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Title: Lateralized P3 deficit in schizotypal personality disorder
Author: Niznikiewicz, Margaret A.; Voglmaier, Martina M.; Shenton, Martha Elizabeth ORCID  0000-0003-4235-7879 ; Dickey, Chandlee C.; Seidman, Larry Joel; Teh, EngKeat; Van Rhoads, Richard; McCarley, Robert William

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Citation: Niznikiewicz, Margaret A, Martina M Voglmaier, Martha E Shenton, Chandlee C Dickey, Larry J Seidman, EngKeat Teh, Richard Van Rhoads, and Robert W McCarley. 2000. “Lateralized P3 Deficit in Schizotypal Personality Disorder.” Biological Psychiatry 48 (7) (October): 702–705. doi:10.1016/s0006-3223(00)00938-0.
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Abstract: Background: Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia and schizotypal personality disorder (SPD). This study was undertaken to determine the replicability of our previous finding of a left-lateralized P3 amplitude deficit in SPD. Methods: We recorded event-related potentials in 21 SPD and 18 normal control subjects in an auditory “oddball” P3 paradigm. Results: In the SPD subjects, but not in the control subjects, there was lower P3 amplitude at T3 compared with T4. Conclusions: These results are similar to the ones in our previous work and further support the presence of a left-lateralized P3 deficit in SPD.
Published Version: doi:10.1016/S0006-3223(00)00938-0
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