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dc.contributor.authorKubicki, Marek R.
dc.contributor.authorWestin, Carl-Fredrik
dc.contributor.authorMaier, Stephan Ernst
dc.contributor.authorFrumin, Melissa
dc.contributor.authorNestor, Paul Gerard
dc.contributor.authorSalisbury, Dean F.
dc.contributor.authorKikinis, Ron
dc.contributor.authorJolesz, Ferenc A.
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-15T19:53:44Z
dc.date.issued2002
dc.identifier.citationKubicki, Marek, Carl-Fredrik Westin, Stephan E. Maier, Melissa Frumin, Paul G. Nestor, Dean F. Salisbury, Ron Kikinis, Ferenc A. Jolesz, Robert W. McCarley, and Martha E. Shenton. 2002. “Uncinate Fasciculus Findings in Schizophrenia: A Magnetic Resonance Diffusion Tensor Imaging Study.” AJP 159 (5) (May): 813–820. doi:10.1176/appi.ajp.159.5.813.en_US
dc.identifier.issn0002-953Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28520523
dc.description.abstractObjective: Disruptions in connectivity between the frontal and temporal lobes may explain some of the symptoms observed in schizophrenia. Conventional magnetic resonance imaging (MRI) studies, however, have not shown compelling evidence for white matter abnormalities, because white matter fiber tracts cannot be visualized by conventional MRI. Diffusion tensor imaging is a relatively new technique that can detect subtle white matter abnormalities in vivo by assessing the degree to which directionally organized fibers have lost their normal integrity. The first three diffusion tensor imaging studies in schizophrenia showed lower anisotropic diffusion, relative to comparison subjects, in whole-brain white matter, prefrontal and temporal white matter, and the corpus callosum, respectively. Here the authors focus on fiber tracts forming temporal-frontal connections. Method: Anisotropic diffusion was assessed in the uncinate fasciculus, the most prominent white matter tract connecting temporal and frontal brain regions, in 15 patients with chronic schizophrenia and 18 normal comparison subjects. A 1.5-T GE Echospeed system was used to acquire 4-mm-thick coronal line-scan diffusion tensor images. Maps of the fractional anisotropy were generated to quantify the water diffusion within the uncinate fasciculus. Results: Findings revealed a group-by-side interaction for fractional anisotropy and for uncinate fasciculus area, derived from automatic segmentation. The patients with schizophrenia showed a lack of normal left-greater-than-right asymmetry seen in the comparison subjects. Conclusions: These findings demonstrate the importance of investigating white matter tracts in vivo in schizophrenia and support the hypothesis of a disruption in the normal pattern of connectivity between temporal and frontal brain regions in schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Psychiatric Publishingen_US
dc.relation.isversionofdoi:10.1176/appi.ajp.159.5.813en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803760/en_US
dash.licenseLAA
dc.titleUncinate Fasciculus Findings in Schizophrenia: A Magnetic Resonance Diffusion Tensor Imaging Studyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalAmerican Journal of Psychiatryen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-15T19:53:44Z
dc.identifier.doi10.1176/appi.ajp.159.5.813*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedFrumin, Melissa
dash.contributor.affiliatedWestin, Carl-Fredrik
dash.contributor.affiliatedMaier, Stephan
dash.contributor.affiliatedJolesz, Ferenc
dash.contributor.affiliatedNestor, Paul
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0001-7227-7058


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