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dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorGerig, Guido
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorSzékely, Gábor
dc.contributor.authorKikinis, Ron
dc.date.accessioned2016-09-15T19:59:08Z
dc.date.issued2002
dc.identifier.citationShenton, Martha E, Guido Gerig, Robert W McCarley, Gábor Székely, and Ron Kikinis. 2002. “Amygdala–hippocampal Shape Differences in Schizophrenia: The Application of 3D Shape Models to Volumetric MR Data.” Psychiatry Research: Neuroimaging 115 (1-2) (August): 15–35. doi:10.1016/s0925-4927(02)00025-2.en_US
dc.identifier.issn0925-4927en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28520526
dc.description.abstractEvidence suggests that some structural brain abnormalities in schizophrenia are neurodevelopmental in origin. There is also growing evidence to suggest that shape deformations in brain structure may reflect abnormalities in neurodevelopment. While many magnetic resonance (MR) imaging studies have investigated brain area and volume measures in schizophrenia, fewer have focused on shape deformations. In this MR study we used a 3D shape representation technique, based on spherical harmonic functions, to analyze left and right amygdala-hippocampus shapes in each of 15 patients with schizophrenia and 15 healthy controls matched for age, gender, handedness and parental socioeconomic status. Left/right asymmetry was also measured for both shape and volume differences. Additionally, shape and volume measurements were combined in a composite analysis. There were no differences between groups in overall volume or shape. Left/right amygdala–hippocampal asymmetry, however, was significantly larger in patients than controls for both relative volume and shape. The local brain regions responsible for the left/right asymmetry differences in patients with schizophrenia were in the tail of the hippocampus (including both the inferior aspect adjacent to parahippocampal gyrus and the superior aspect adjacent to the lateral geniculate nucleus and more anteriorly to the cerebral peduncles) and in portions of the amygdala body (including the anterior–superior aspect adjacent to the basal nucleus). Also, in patients, increased volumetric asymmetry tended to be correlated with increased left/right shape asymmetry. Furthermore, a combined analysis of volume and shape asymmetry resulted in improved differentiation between groups. Classification function analyses correctly classified 70% of cases using volume, 73.3% using shape, and 87% using combined volume and shape measures. These findings suggest that shape provides important new information toward characterizing the pathophysiology of schizophrenia, and that combining volume and shape measures provides improved group discrimination in studies investigating brain abnormalities in schizophrenia. An evaluation of shape deformations also suggests local abnormalities in the amygdala–hippocampal complex in schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/s0925-4927(02)00025-2en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824647/en_US
dash.licenseLAA
dc.subjectschizophreniaen_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectAmygdala–hippocampal complexen_US
dc.subjecthippocampusen_US
dc.subjectneurodevelopmental abnormalitiesen_US
dc.subjectshape deformationsen_US
dc.subjectshape analysisen_US
dc.subjectThree-dimensional (3D) shape techniquesen_US
dc.subjectshape descriptorsen_US
dc.titleAmygdala–hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR dataen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalPsychiatry Research: Neuroimagingen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-15T19:59:08Z
dc.identifier.doi10.1016/s0925-4927(02)00025-2*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0001-7227-7058


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