An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia

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An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia

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Title: An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia
Author: Anderson, Jane E; Wible, Cynthia Gayle; McCarley, Robert William; Jakab, M; Kasai, Kazue; Shenton, Martha Elizabeth ORCID  0000-0003-4235-7879

Note: Order does not necessarily reflect citation order of authors.

Citation: ANDERSON, J, C WIBLE, R MCCARLEY, M JAKAB, K KASAI, and M SHENTON. 2002. An MRI Study of Temporal Lobe Abnormalities and Negative Symptoms in Chronic Schizophrenia. Schizophrenia Research 58, no. 2-3: 123–134. doi:10.1016/s0920-9964(01)00372-3. http://dx.doi.org/10.1016/s0920-9964(01)00372-3.
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Abstract: Previous magnetic resonance imaging (MRI) studies have reported various subtle brain abnormalities in schizophrenic patients, including temporal lobe abnormalities, which are of particular interest given the role of this brain region in auditory and language processing, and the characteristic deficits in these processes in schizophrenia. Subjects in this study were 16 male patients diagnosed with chronic schizophrenia and 15 healthy male comparison subjects. These patients were characterized by negative symptoms. High spatial resolution coronal MRI 1.5-mm-thick slices were used to measure the gray matter volume of the superior temporal gyrus, anterior and posterior amygdala/hippocampal complex, and parahippocampal gyrus. Patients, relative to normal comparison subjects, evinced a reduction of gray matter volume in bilateral superior temporal gyri and anterior amygdala/hippocampal complex. The reduction in gray matter of the superior temporal gyrus in patients with schizophrenia is consistent with previous findings, and is noteworthy in that it was found in this group of patients with predominantly negative symptoms. The reduction in the anterior amygdala/hippocampal complex was an additional temporal lobe finding. These results underscore the role of temporal lobe structures in the pathophysiology of schizophrenia.
Published Version: doi:10.1016/s0920-9964(01)00372-3
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845171/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:28520533
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