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dc.contributor.authorPasternak, Ofer
dc.contributor.authorWestin, Carl-Fredrik
dc.contributor.authorBouix, Sylvain
dc.contributor.authorSeidman, Larry Joel
dc.contributor.authorGoldstein, Jill M.
dc.contributor.authorWoo, Tsung-Ung Wilson
dc.contributor.authorPetryshen, Tracey Lynn
dc.contributor.authorMesholam-Gately, Raquelle
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorKikinis, Ron
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorKubicki, Marek R.
dc.date.accessioned2016-09-20T17:43:56Z
dc.date.issued2012
dc.identifier.citationPasternak, O., C.-F. Westin, S. Bouix, L. J. Seidman, J. M. Goldstein, T.-U. W. Woo, T. L. Petryshen, et al. 2012. “Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset.” Journal of Neuroscience 32 (48) (November 28): 17365–17372. doi:10.1523/jneurosci.2904-12.2012.en_US
dc.identifier.issn0270-6474en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28538475
dc.description.abstractDiffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the role of these abnormalities in the etiology of schizophrenia is not well understood. Accumulating evidence from imaging, histological, genetic, and immunochemical studies support the involvement of axonal degeneration and neuroinflammation—ubiquitous components of neurodegenerative disorders—as the underlying pathologies of these abnormalities. Nevertheless, the current imaging modalities cannot distinguish neuroinflammation from axonal degeneration, and therefore provide little specificity with respect to the pathophysiology progression and whether it is related to a neurodegenerative process. Free-water imaging is a new methodology that is sensitive to water molecules diffusing in the extracellular space. Excessive extracellular volume is a surrogate biomarker for neuroinflammation and can be separated out to reveal abnormalities such as axonal degeneration that affect diffusion characteristics in the tissue. We applied free-water imaging on diffusion MRI data acquired from schizophrenia-diagnosed human subjects with a first psychotic episode. We found a significant increase in the extracellular volume in both white and gray matter. In contrast, significant signs of axonal degeneration were limited to focal areas in the frontal lobe white matter. Our findings demonstrate that neuroinflammation is more prominent than axonal degeneration in the early stage of schizophrenia, revealing a pattern shared by many neurodegenerative disorders, in which prolonged inflammation leads to axonal degeneration. These findings promote anti-inflammatory treatment for early diagnosed schizophrenia patients.en_US
dc.description.sponsorshipPsychologyen_US
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionofdoi:10.1523/jneurosci.2904-12.2012en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549332/en_US
dash.licenseLAA
dc.titleExcessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onseten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Neuroscienceen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-20T17:43:56Z
dc.identifier.doi10.1523/jneurosci.2904-12.2012*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedWestin, Carl-Fredrik
dash.contributor.affiliatedWoo, Tsung-Ung
dash.contributor.affiliatedGoldstein, Jill
dash.contributor.affiliatedMesholam-Gately, Raquelle
dash.contributor.affiliatedPetryshen, Tracey L.
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedSeidman, Larry Joel
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedPasternak, Ofer
dash.contributor.affiliatedBouix, Sylvain
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0001-7227-7058


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