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dc.contributor.authorWassermann, Demian
dc.contributor.authorMakris, Nikos
dc.contributor.authorRathi, Yogesh
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorKikinis, Ron
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorWestin, Carl-Fredrik
dc.date.accessioned2016-09-20T17:47:47Z
dc.date.issued2013
dc.identifier.citationWassermann, Demian, Nikos Makris, Yogesh Rathi, Martha Shenton, Ron Kikinis, Marek Kubicki, and Carl-Fredrik Westin. 2013. “On Describing Human White Matter Anatomy: The White Matter Query Language.” Lecture Notes in Computer Science: 647–654. doi:10.1007/978-3-642-40811-3_81.en_US
dc.identifier.issn0302-9743en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28538477
dc.description.abstractThe main contribution of this work is the careful syntactical definition of major white matter tracts in the human brain based on a neuroanatomist’s expert knowledge. We present a technique to formally describe white matter tracts and to automatically extract them from diffusion MRI data. The framework is based on a novel query language with a near-to-English textual syntax. This query language allows us to construct a dictionary of anatomical definitions describing white matter tracts. The definitions include adjacent gray and white matter regions, and rules for spatial relations. This enables automated coherent labeling of white matter anatomy across subjects. We use our method to encode anatomical knowledge in human white matter describing 10 association and 8 projection tracts per hemisphere and 7 commissural tracts. The technique is shown to be comparable in accuracy to manual labeling. We present results applying this framework to create a white matter atlas from 77 healthy subjects, and we use this atlas in a proof-of-concept study to detect tract changes specific to schizophrenia.en_US
dc.description.sponsorshipPsychologyen_US
dc.language.isoen_USen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.relation.isversionofdoi:10.1007/978-3-642-40811-3_81en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029160/en_US
dash.licenseLAA
dc.titleOn Describing Human White Matter Anatomy: The White Matter Query Languageen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalLecture Notes in Computer Scienceen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-20T17:47:47Z
dc.identifier.doi10.1007/978-3-642-40811-3_81*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedWestin, Carl-Fredrik
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedRathi, Yogesh
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-7227-7058


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