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dc.contributor.authorYang, Jimmy Chen
dc.contributor.authorPapadimitriou, George
dc.contributor.authorEckbo, Ryan
dc.contributor.authorYeterian, Edward H.
dc.contributor.authorLiang, Lichen
dc.contributor.authorDougherty, Darin Dean
dc.contributor.authorBouix, Sylvain
dc.contributor.authorRathi, Yogesh
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorEskandar, Emad
dc.contributor.authorMakris, Nikos
dc.date.accessioned2016-09-20T17:52:52Z
dc.date.issued2014
dc.identifier.citationYang, Jimmy C., George Papadimitriou, Ryan Eckbo, Edward H. Yeterian, Lichen Liang, Darin D. Dougherty, Sylvain Bouix, et al. 2014. “Multi-Tensor Investigation of Orbitofrontal Cortex Tracts Affected in Subcaudate Tractotomy.” Brain Imaging and Behavior 9 (2) (August 8): 342–352. doi:10.1007/s11682-014-9314-z.en_US
dc.identifier.issn1931-7557en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28538479
dc.description.abstractSubcaudate tractotomy (SCT) is a neurosurgical lesioning procedure that can reduce symptoms in medically intractable obsessive compulsive disorder (OCD). Due to the putative importance the orbitofrontal cortex (OFC) in symptomatology, fibers that connect the OFC, SCT lesion, and either the thalamus or brainstem were investigated with two-tensor tractography using an unscented Kalman filter approach. From this dataset, fibers were warped to Montreal Neurological Institute space, and probability maps with center-of-mass analysis were subsequently generated. In comparing fibers from the same OFC region, including medial OFC (mOFC), central OFC (cOFC), and lateral OFC (lOFC), the area of divergence for fibers connected with the thalamus versus the brainstem is posterior to the anterior commissure. At the anterior commissure, fibers connected with the thalamus run dorsal to those connected with the brainstem. As OFC fibers travel through the ventral aspect of the internal capsule, lOFC fibers are dorsal to cOFC and mOFC fibers. Using neuroanatomical comparison, tracts coursing between the OFC and thalamus are likely part of the anterior thalamic radiations, while those between the OFC and brainstem likely belong to the medial forebrain bundle. These data support the involvement of the OFC in OCD and may be relevant to creating differential lesional procedures of specific tracts or to developing deep brain stimulation programming paradigms.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.relation.isversionofdoi:10.1007/s11682-014-9314-zen_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320992/en_US
dash.licenseOAP
dc.subjectpsychosurgeryen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectdiffusion tractographyen_US
dc.subjectobsessive-compulsive disorderen_US
dc.subjectdeep brain stimulationen_US
dc.titleMulti-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalBrain Imaging and Behavioren_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-20T17:52:52Z
dc.identifier.doi10.1007/s11682-014-9314-z*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedYang, Jimmy
dash.contributor.affiliatedDougherty, Darin
dash.contributor.affiliatedBouix, Sylvain
dash.contributor.affiliatedRathi, Yogesh
dash.contributor.affiliatedEskandar, Emad
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0003-4235-7879


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