Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia

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Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia

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Title: Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia
Author: Wigand, Marlene; Kubicki, Marek R.; Clemm von Hohenberg, Christian; Leicht, Gregor; Karch, Susanne; Eckbo, Ryan; Pelavin, Paula E.; Hawley, Kathryn; Rujescu, Dan; Bouix, Sylvain; Shenton, Martha Elizabeth ORCID  0000-0003-4235-7879 ; Mulert, Christoph

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Citation: Wigand, Marlene, Marek Kubicki, Christian Clemm von Hohenberg, Gregor Leicht, Susanne Karch, Ryan Eckbo, Paula E. Pelavin, et al. 2014. “Auditory Verbal Hallucinations and the Interhemispheric Auditory Pathway in Chronic Schizophrenia.” The World Journal of Biological Psychiatry 16 (1) (September 16): 31–44. doi:10.3109/15622975.2014.948063.
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Abstract: Objectives—The interhemispheric auditory pathway has been shown to play a crucial role in the processing of acoustic stimuli, and alterations of structural and functional connectivity between bilateral auditory areas are likely relevant to the pathogenesis of auditory verbal hallucinations (AVHs). The aim of this study was to examine this pathway in patients with chronic schizophrenia regarding their lifetime history of AVHs. Methods—DTI scans were acquired from 33 healthy controls (HC), 24 schizophrenia patients with a history of AVHs (LT-AVH) and 9 schizophrenia patients without any lifetime hallucinations (N-LT-AVH). The interhemispheric auditory fibre bundles were extracted using streamline tractography. Subsequently, diffusivity indices, namely Fractional Anisotropy (FA), Trace, Mode, Axial and Radial Diffusivity, were calculated.Results—FA was decreased over the entire pathway in LT-AVH compared with N-LT-AVH. Moreover, LT-AVH displayed decreased FA and Mode as well as increased Radial Diffusivity in the midsagittal section of the fibre tract. Conclusions—These findings indicate complex microstructural changes in the interhemispheric auditory pathway of schizophrenia patients with a history of AVHs. Alterations appear to be absent in patients who have never hallucinated.
Published Version: doi:10.3109/15622975.2014.948063
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698973/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:28538485
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