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dc.contributor.authorWoodberry, Kristen Anne
dc.contributor.authorSerur, Rachael A.
dc.contributor.authorHallinan, Sean B.
dc.contributor.authorMesholam-Gately, Raquelle
dc.contributor.authorGiuliano, Anthony J.
dc.contributor.authorWojcik, Joanne Doller
dc.contributor.authorKeshavan, Matcheri S
dc.contributor.authorFrazier, Jean A.
dc.contributor.authorGoldstein, Jill M.
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorSeidman, Larry Joel
dc.date.accessioned2016-09-20T18:09:13Z
dc.date.issued2014
dc.identifier.citationWoodberry, Kristen A., Rachael A. Serur, Sean B. Hallinan, Raquelle I. Mesholam-Gately, Anthony J. Giuliano, Joanne D. Wojcik, Matcheri S. Keshavan, et al. 2014. “Frequency and Pattern of Childhood Symptom Onset Reported by First Episode Schizophrenia and Clinical High Risk Youth.” Schizophrenia Research 158 (1-3) (September): 45–51. doi:10.1016/j.schres.2014.05.017.en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28538488
dc.description.abstractBackground—Psychosis prevention and early intervention efforts in schizophrenia have focused increasingly on sub-threshold psychotic symptoms in adolescents and young adults. Although many youth report symptom onset prior to adolescence, the childhood incidence of prodromal level symptoms in those with schizophrenia or related psychoses is largely unknown. Methods—This study reports on the retrospective recall of prodromal-level symptoms from 40 participants in a first-episode of schizophrenia (FES) and 40 participants at “clinical high risk” (CHR) for psychosis. Onset of positive and non-specific symptoms was captured using the Structured Interview for Prodromal Syndromes. Frequencies are reported according to onset during childhood (prior to age 13), adolescence (13–17), or adulthood (18 +). Results—Childhood-onset of attenuated psychotic symptoms was not rare. At least 11% of FES and 23% of CHR reported specific recall of childhood-onset of unusual or delusional ideas, suspiciousness, or perceptual abnormalities. Most recalled experiencing non-specific symptoms prior to positive symptoms. CHR and FES did not differ significantly in the timing of positive and non-specific symptom onset. Other than being younger at assessment, those with childhood onset did not differ demographically from those with later onset. Conclusion—Childhood-onset of initial psychotic-like symptoms may be more common than previous research has suggested. Improved characterization of these symptoms and a focus on their predictive value for subsequent schizophrenia and other major psychoses are needed to facilitate screening of children presenting with attenuated psychotic symptoms. Accurate detection of prodromal symptoms in children might facilitate even earlier intervention and the potential to alter pre-illness trajectories.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.schres.2014.05.017en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207713/en_US
dash.licenseOAP
dc.subjectChilden_US
dc.subjectPsychosisen_US
dc.subjectPsychotic-likeen_US
dc.subjectSIPSen_US
dc.subjectProdromeen_US
dc.subjectEarly onseten_US
dc.titleFrequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youthen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSchizophrenia Researchen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-20T18:09:13Z
dc.identifier.doi10.1016/j.schres.2014.05.017*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedGoldstein, Jill
dash.contributor.affiliatedWoodberry, Kristen
dash.contributor.affiliatedMesholam-Gately, Raquelle
dash.contributor.affiliatedSeidman, Larry Joel
dash.contributor.affiliatedKeshavan, Matcheri
dash.contributor.affiliatedWojcik, Joanne
dash.contributor.affiliatedShenton, Martha
dash.contributor.affiliatedMcCarley, Robert William
dc.identifier.orcid0000-0001-5705-7495


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