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dc.contributor.authorThermenos, Heidi Wencel
dc.contributor.authorWhitfield-Gabrieli, S.
dc.contributor.authorSeidman, Larry Joel
dc.contributor.authorKuperberg, Gina Rosalind
dc.contributor.authorJuelich, R.J.
dc.contributor.authorDivatia, S.
dc.contributor.authorRiley, C.
dc.contributor.authorJabbar, G.A.
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorManschreck, Theo Clyde
dc.contributor.authorKeshavan, Matcheri S
dc.contributor.authorDeLisi, Lynn E
dc.date.accessioned2016-09-20T20:28:32Z
dc.date.issued2013
dc.identifier.citationThermenos, H.W., S. Whitfield-Gabrieli, L.J. Seidman, G. Kuperberg, R.J. Juelich, S. Divatia, C. Riley, et al. 2013. “Altered Language Network Activity in Young People at Familial High-Risk for Schizophrenia.” Schizophrenia Research 151 (1-3) (December): 229–237. doi:10.1016/j.schres.2013.09.023.en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28539564
dc.description.abstractBackground—Abnormalities in language and language neural circuitry are observed in schizophrenia (SZ). Similar, but less pronounced language deficits are also seen in young first degree relatives of people with SZ, who are at higher familial risk (FHR) for the disorder than the general population. The neural underpinnings of these deficits in people with FHR are unclear. Methods—Participants were 43 people with FHR and 32 comparable controls. fMRI scans were collected while participants viewed associated and unrelated word pairs, and performed a lexical decision task. fMRI analyses conducted in SPM8 examined group differences in the modulation of hemodynamic activity by semantic association. Results—There were no group differences in demographics, IQ or behavioral semantic priming, but FHR participants had more schizotypal traits than controls. Controls exhibited the expected suppression of hemodynamic activity to associated versus unrelated word pairs. Compared to controls, FHR participants showed an opposite pattern of hemodynamic modulation to associated versus unrelated word pairs, in the left inferior frontal gyrus (IFG), right superior and middle temporal gyrus (STG) and the left cerebellum. Group differences in activation were significant, FWE-corrected for multiple comparisons (p<0.05). Activity within the IFG during the unrelated condition predicted schizotypal symptoms in FHR participants. Conclusions—FHR for SZ is associated with abnormally increased neural activity to semantic associates within an inferior frontal/temporal network. This might increase the risk of developing unusual ideas, perceptions and disorganized language that characterize schizotypal traits, potentially predicting which individuals are at greater risk to develop a psychotic disorder.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.schres.2013.09.023en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987706/en_US
dash.licenseLAA
dc.subjectSchizophreniaen_US
dc.subjectFunctional MRen_US
dc.subjectHigh-risken_US
dc.subjectlanguageen_US
dc.subjectgeneticsen_US
dc.subjectsemantic primingen_US
dc.titleAltered language network activity in young people at familial high-risk for schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSchizophrenia Researchen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-20T20:28:32Z
dc.identifier.doi10.1016/j.schres.2013.09.023*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedKuperberg, Gina
dash.contributor.affiliatedManschreck, Theo
dash.contributor.affiliatedThermenos, Heidi
dash.contributor.affiliatedDeLisi, Lynn
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedSeidman, Larry Joel
dash.contributor.affiliatedKeshavan, Matcheri
dash.contributor.affiliatedShenton, Martha


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