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dc.contributor.authorEgger, Karl
dc.contributor.authorClemm von Hohenberg, Christian
dc.contributor.authorSchocke, Michael F.
dc.contributor.authorGuttmann, Charles R.G.
dc.contributor.authorWassermann, Demian
dc.contributor.authorWigand, Marlene C.
dc.contributor.authorNachbauer, Wolfgang
dc.contributor.authorKremser, Christian
dc.contributor.authorSturm, Brigitte
dc.contributor.authorScheiber-Mojdehkar, Barbara
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorBoesch, Sylvia
dc.date.accessioned2016-09-20T20:30:21Z
dc.date.issued2013
dc.identifier.citationEgger, Karl, Christian Clemm von Hohenberg, Michael F. Schocke, Charles R.G. Guttmann, Demian Wassermann, Marlene C. Wigand, Wolfgang Nachbauer, et al. 2013. “White Matter Changes in Patients with Friedreich Ataxia after Treatment with Erythropoietin.” Journal of Neuroimaging 24 (5) (September 9): 504–508. doi:10.1111/jon.12050.en_US
dc.identifier.issn1051-2284en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28539565
dc.description.abstractBackground and Purpose—Erythropoietin (EPO) has received growing attention because of its neuro-regenerative properties. Preclinical and clinical evidence supports its therapeutic potential in brain conditions like stroke, multiple sclerosis and schizophrenia. Also in Friedreich ataxia, clinical improvement after EPO therapy was shown. The aim of the present study was to assess possible therapy-associated brain white-matter changes in these patients.Methods—Nine patients with Friedreich ataxia underwent Diffusion Tensor Imaging (DTI) before and after EPO treatment. Tract-based spatial statistics (TBSS) was used for longitudinal comparison. Results—We detected widespread longitudinal increase in fractional anisotropy (FA) and axial diffusivity (D||) in cerebral hemispheres bilaterally (p<0.05, corrected), while no changes were observed within the cerebellum, medulla oblongata and pons. Conclusions—To the best of our knowledge, this is the first DTI study to investigate the effects of erythropoietin in a neurodegenerative disease. Anatomically, the diffusivity changes appear disease-unspecific, and their biological underpinnings deserve further study.en_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionofdoi:10.1111/jon.12050en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950637/en_US
dash.licenseLAA
dc.titleWhite Matter Changes in Patients with Friedreich Ataxia after Treatment with Erythropoietinen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalJ Neuroimagingen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-20T20:30:21Z
dc.identifier.doi10.1111/jon.12050*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedGuttmann, Charles
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0003-4235-7879


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