Show simple item record

dc.contributor.authorKikinis, Zora
dc.contributor.authorMakris, Nikos
dc.contributor.authorFinn, Christine
dc.contributor.authorBouix, Sylvain
dc.contributor.authorLucia, Diandra
dc.contributor.authorColeman, Michael James
dc.contributor.authorTworog-Dube, Erica
dc.contributor.authorKikinis, Ron
dc.contributor.authorKucherlapati, Raju
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorKubicki, Marek R.
dc.date.accessioned2016-09-20T20:31:44Z
dc.date.issued2013
dc.identifier.citationKikinis, Zora, Nikos Makris, Christine T. Finn, Sylvain Bouix, Diandra Lucia, Michael J. Coleman, Erica Tworog-Dube, et al. 2013. “Genetic Contributions to Changes of Fiber Tracts of Ventral Visual Stream in 22q11.2 Deletion Syndrome.” Brain Imaging and Behavior 7 (3) (April 24): 316–325. doi:10.1007/s11682-013-9232-5.en_US
dc.identifier.issn1931-7557en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28539566
dc.description.abstractPatients with 22q11.2 deletion syndrome (22q11.2DS) represent a population at high risk for developing schizophrenia, as well as learning disabilities. Deficits in visuo-spatial memory are thought to underlie some of the cognitive disabilities. Neuronal substrates of visuo-spatial memory include the inferior fronto-occipital fasciculus (IFOF) and the inferior longitudinal fasciculus (ILF), two tracts that comprise the ventral visual stream. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) is an established method to evaluate white matter (WM) connections in vivo. DT-MRI scans of nine 22q11.2DS young adults and nine matched healthy subjects were acquired. Tractography of the IFOF and the ILF was performed. DT-MRI indices, including Fractional anisotropy (FA) (measure of WM changes), axial diffusivity (AD, measure of axonal changes) and radial diffusivity (RD, measure of myelin changes) of each of the tracts and each group were measured and compared. The 22q11.2DS group showed statistically significant reductions of FA in IFOF in the left hemisphere. Additionally, reductions of AD were found in the IFOF and the ILF in both hemispheres. These findings might be the consequence of axonal changes, which is possibly due to fewer, thinner, or less organized fibers. No changes in RD were detected in any of the tracts delineated, which is in contrast to findings in schizophrenia patients where increases in RD are believed to be indicative of demyelination. We conclude that reduced axonal changes may be key to understanding the underlying pathology of WM leading to the visuo-spatial phenotype in 22q11.2DS.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.relation.isversionofdoi:10.1007/s11682-013-9232-5en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796180/en_US
dash.licenseLAA
dc.subject22q11.2 deletion syndrome (22q11.2DS,CFS)en_US
dc.subjectDiffusion Tensor MRI (DT-MRI)en_US
dc.subjectfractional anisotropyen_US
dc.subjectaxial diffusivityen_US
dc.subjectinferior fronto-occipital fasciculusen_US
dc.subjectinferior longitudinal fasciculusen_US
dc.subjecthigh-risk schizophreniaen_US
dc.titleGenetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndromeen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalBrain Imaging and Behavioren_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-20T20:31:44Z
dc.identifier.doi10.1007/s11682-013-9232-5*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedFinn, Christine
dash.contributor.affiliatedColeman, Michael
dash.contributor.affiliatedKucherlapati, Raju
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedKikinis, Zora
dash.contributor.affiliatedBouix, Sylvain
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-7227-7058


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record