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dc.contributor.authorRomo-Nava, F.
dc.contributor.authorHoogenboom, W.S.
dc.contributor.authorPelavin, P.E.
dc.contributor.authorAlvarado, J.L.
dc.contributor.authorBobrow, L.H.
dc.contributor.authorMacMaster, F.P.
dc.contributor.authorKeshavan, Matcheri S
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-20T20:42:21Z
dc.date.issued2013
dc.identifier.citationRomo-Nava, F., W.S. Hoogenboom, P.E. Pelavin, J.L. Alvarado, L.H. Bobrow, F.P. MacMaster, M. Keshavan, R.W. McCarley, and M.E. Shenton. 2013. “Pituitary Volume in Schizophrenia Spectrum Disorders.” Schizophrenia Research 146 (1-3) (May): 301–307. doi:10.1016/j.schres.2013.02.024.en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28539575
dc.description.abstractIntroduction—There is converging evidence supporting hyperactivity of the HypothalamicPituitary-Adrenal (HPA) axis in schizophrenia spectrum disorders (SSD), such as schizotypal personality disorder (SPD), first-episode schizophrenia (FESZ) and chronic schizophrenia (CHSZ). Such an aberrant HPA activity might have volumetric consequences on the pituitary gland. However, previous magnetic resonance imaging (MRI) studies assessing pituitary volume (PV) in SSD are conflicting. The main objective of this study was to examine further PV in SSD. Methods—PV were manually traced on structural MRIs in 137 subjects, including subjects with SPD (n=40), FESZ (n=15), CHSZ (n=15), and HC (n=67). We used an ANCOVA to test PV between groups and gender while controlling for inter-subject variability in age, years of education, socioeconomic status, and whole brain volume. Results—Overall, women had larger PV than men, and within the male sample all SSD subjects had smaller PV than HC, statistically significant only for the SPD group. In addition, dose of medication, illness duration and age of onset were not associated with PV. Conclusion—Chronic untreated HPA hyperactivity might account for smaller PV in SPD subjects, whereas the absence of PV changes in FESZ and CHSZ patients might be related to the normalizing effects of antipsychotics on PV. SPD studies offer a way to examine HPA related alterations in SSD without the potential confounds of medication effects.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.schres.2013.02.024en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760333/en_US
dash.licenseLAA
dc.subjectschizophreniaen_US
dc.subjectfirst-episodeen_US
dc.subjectschizotypalen_US
dc.subjectpituitary volumeen_US
dc.subjectMRIen_US
dc.titlePituitary volume in schizophrenia spectrum disordersen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSchizophrenia Researchen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-20T20:42:21Z
dc.identifier.doi10.1016/j.schres.2013.02.024*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedKeshavan, Matcheri
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495


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