Disruption of function–structure coupling in brain regions sub-serving self monitoring in schizophrenia

DSpace/Manakin Repository

Disruption of function–structure coupling in brain regions sub-serving self monitoring in schizophrenia

Citable link to this page

 

 
Title: Disruption of function–structure coupling in brain regions sub-serving self monitoring in schizophrenia
Author: Araki, Tsuyoshi; Niznikiewicz, Margaret A.; Kawashima, Toshiro; Nestor, Paul Gerard; Shenton, Martha Elizabeth ORCID  0000-0003-4235-7879 ; McCarley, Robert William

Note: Order does not necessarily reflect citation order of authors.

Citation: Araki, Tsuyoshi, Margaret Niznikiewicz, Toshiro Kawashima, Paul G. Nestor, Martha E. Shenton, and Robert W. McCarley. 2013. Disruption of Function–structure Coupling in Brain Regions Sub-Serving Self Monitoring in Schizophrenia. Schizophrenia Research 146, no. 1-3: 336–343. doi:10.1016/j.schres.2013.02.028.
Full Text & Related Files:
Abstract: Deficits in self monitoring are a core feature of cognitive dysfunction in schizophrenia, and may be the basis for disturbances of self and lack of insight, ultimately impacting social functioning. However, the functional and structural neural correlates of such deficits in self monitoring are not well understood. We investigated this issue using measurements of neurophysiological and structural brain indices, i.e., error-related and correct-response negativity (ERN & CRN) of eventrelated potentials, and gray matter volume of the anterior cingulate cortex (ACC), and tested whether the association between these indices is altered in patients with schizophrenia. Participants consisted of 18 male patients with chronic schizophrenia and 18 healthy male controls. The 2 groups did not differ in ERN amplitude. In contrast, schizophrenia patients showed significantly larger CRN amplitudes than did healthy subjects. Although the 2 groups did not significantly differ in gray matter volume of the ACC subregions, a significant negative correlation was found between ERN amplitudes at the frontocentral electrodes and absolute gray matter volumes of the left cognitive region of ACC only in healthy controls. These results suggest a disruption of function-structure coupling of the brain regions sub-serving self monitoring in schizophrenia.
Published Version: doi:10.1016/j.schres.2013.02.028
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634126/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:28548721
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters