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dc.contributor.authorAsami, Takeshi
dc.contributor.authorSaito, Yukiko
dc.contributor.authorWhitford, Thomas
dc.contributor.authorMakris, Nikos
dc.contributor.authorNiznikiewicz, Margaret A.
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorKubicki, Marek R.
dc.date.accessioned2016-09-22T20:32:58Z
dc.date.issued2013
dc.identifier.citationAsami T, Saito Y, Whitford TJ, Makris N, Niznikiewicz M, McCarley RW, Shenton ME, Kubicki M. 2013. Abnormalities of middle longitudinal fascicle and disorganization in patients with schizophrenia. Schizophr Res 143, no. 2-3:253-9. doi:10.1016/j.schres.2012.11.030en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28548724
dc.description.abstractIntroduction—The Middle Longitudinal Fascicle (MdLF) is a long association fiber connecting the superior temporal gyrus (STG) and temporal pole with the angular gyrus through the white matter of the STG, structures which are known to play a crucial role in the pathology of schizophrenia. Functions of MdLF are thought to be related to language and thought processing in the left hemisphere, and with attention in the right hemisphere. While deficits of these functions are core clinical features of schizophrenia, no study has investigated structural abnormalities of MdLF in schizophrenia. Method—3T diffusion tensor data was acquired from twenty-six patients with schizophrenia and twenty-five healthy control subjects. Streamline tractography technique was used to extract MdLF. Fractional Anisotropy (FA) was compared between two groups. In addition, relationships were investigated between FA in the left MdLF and the Disorganized Thought Factor derived from the Positive and Negative Symptom Scale five factor model, and between FA in the right MdLF and the Poor Attention. Result—Relative to control subjects, the patients with chronic schizophrenia showed significant mean FA reductions in the bilateral MdLF. The FA of the left MdLF demonstrated a significant negative association with the Disorganized thoughts factor, and the FA of the right MdLF showed a significant negative relationship with the Poor Attention. Conclusions—This study provides new evidence for structural deficits in the bilateral MdLF in patients with chronic schizophrenia. It further demonstrates contribution of these abnormalities to the core clinical features - especially to disorganization and attention deficit.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.schres.2012.11.030en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587354/en_US
dash.licenseLAA
dc.subjectschizophreniaen_US
dc.subjectDTIen_US
dc.subjectFAen_US
dc.subjectmiddle longitudinal fascicleen_US
dc.subjectdisorganizationen_US
dc.subjectattention deficiten_US
dc.titleAbnormalities of middle longitudinal fascicle and disorganization in patients with schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSchizophrenia Researchen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-22T20:32:58Z
dc.identifier.doi10.1016/j.schres.2012.11.030*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedWhitford, T
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedShenton, Martha
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedNiznikiewicz, Margaret
dc.identifier.orcid0000-0003-4235-7879
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0003-3191-2005


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