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dc.contributor.authorLee, Sang-Hyuk
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorAsami, Takeshi
dc.contributor.authorSeidman, Larry Joel
dc.contributor.authorGoldstein, Jill M.
dc.contributor.authorMesholam-Gately, Raquelle
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-22T20:35:10Z
dc.date.issued2013
dc.identifier.citationLee, Sang-Hyuk, Marek Kubicki, Takeshi Asami, Larry J. Seidman, Jill M. Goldstein, Raquelle I. Mesholam-Gately, Robert W. McCarley, and Martha E. Shenton. 2013. Extensive White Matter Abnormalities in Patients with First-Episode Schizophrenia: A Diffusion Tensor Imaging (DTI) Study. Schizophrenia Research 143, no. 2-3: 231–238. doi:10.1016/j.schres.2012.11.029.en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28548725
dc.description.abstractBackground—Previous voxelwise Diffusion Tensor Imaging (DTI) investigations of white matter in first-episode schizophrenia (FESZ) have been limited to the analysis of Fractional Anisotropy (FA) and mean diffusivity (MD), with their findings inconsistent in terms of the anatomical locations and extent of abnormalities. This study examines white matter abnormalities in FESZ, compared with healthy controls, using a tract-based spatial statistics (TBSS) approach applied to multiple measures of tract integrity, and correlates these findings with symptom severity. Methods—Seventeen first-episode patients with schizophrenia and seventeen age- and gender matched healthy controls (HC) participated in this imaging study where FA, MD, and axial and radial diffusivity were compared between the two groups using TBSS. Results—First-episode patients with schizophrenia showed lower FA values in the genu and body of corpus callosum, the internal capsule, the external capsule, the fornix, the superior, inferior fronto-occipital fasciculus, the cingulum, and the uncinate fasciculus compared with HC. Increased MD and radial diffusivity were shown in virtually all white matter regions. There was no significant difference, however, observed for axial diffusivity between the two groups. Pearson correlation analysis showed that the FA values of the right inferior fronto-occipital fasciculus were positively correlated with positive symptoms, negative symptoms, and total correct items of the Wisconsin Card Sorting Test. FA values of right external capsule also showed significant positive correlation with category completed scores of the WCST. Conclusions—These data suggest extensive, possibly myelin related white matter disruptions in FESZ.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.schres.2012.11.029en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354799/en_US
dash.licenseLAA
dc.subjectfirst-episode schizophreniaen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectfractional anisotropyen_US
dc.subjectTBSSen_US
dc.subjectradial diffusivityen_US
dc.subjectmyelinen_US
dc.titleExtensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) studyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSchizophrenia Researchen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-22T20:35:10Z
dc.identifier.doi10.1016/j.schres.2012.11.029*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedGoldstein, Jill
dash.contributor.affiliatedMesholam-Gately, Raquelle
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedSeidman, Larry Joel
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495


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