Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: A pilot study

DSpace/Manakin Repository

Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: A pilot study

Citable link to this page

 

 
Title: Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: A pilot study
Author: Kikinis, Zora; Asami, T.; Bouix, Sylvain; Finn, C.T.; Ballinger, T.; Tworog-Dube, E.; Kucherlapati, Raju; Kikinis, Ron; Shenton, Martha Elizabeth ORCID  0000-0003-4235-7879 ; Kubicki, Marek R.

Note: Order does not necessarily reflect citation order of authors.

Citation: Kikinis, Z., T. Asami, S. Bouix, C.T. Finn, T. Ballinger, E. Tworog-Dube, R. Kucherlapati, R. Kikinis, M.E. Shenton, and M. Kubicki. 2012. Reduced Fractional Anisotropy and Axial Diffusivity in White Matter in 22q11.2 Deletion Syndrome: A Pilot Study. Schizophrenia Research 141, no. 1: 35–39. doi:10.1016/j.schres.2012.06.032.
Full Text & Related Files:
Abstract: Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) and Axial Diffusivity (AD; measure of axonal integrity) in WM underlying the left parietal lobe. No changes in Radial Diffusivity (RD; measure of myelin integrity) were observed. Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructure in 22q11.2DS than in patients with schizophrenia.
Published Version: doi:10.1016/j.schres.2012.06.032
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462006/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:28548730
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters