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dc.contributor.authorKikinis, Zora
dc.contributor.authorAsami, T.
dc.contributor.authorBouix, Sylvain
dc.contributor.authorFinn, C.T.
dc.contributor.authorBallinger, T.
dc.contributor.authorTworog-Dube, E.
dc.contributor.authorKucherlapati, Raju
dc.contributor.authorKikinis, Ron
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorKubicki, Marek R.
dc.date.accessioned2016-09-22T20:52:04Z
dc.date.issued2012
dc.identifier.citationKikinis, Z., T. Asami, S. Bouix, C.T. Finn, T. Ballinger, E. Tworog-Dube, R. Kucherlapati, R. Kikinis, M.E. Shenton, and M. Kubicki. 2012. Reduced Fractional Anisotropy and Axial Diffusivity in White Matter in 22q11.2 Deletion Syndrome: A Pilot Study. Schizophrenia Research 141, no. 1: 35–39. doi:10.1016/j.schres.2012.06.032.en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28548730
dc.description.abstractIndividuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) and Axial Diffusivity (AD; measure of axonal integrity) in WM underlying the left parietal lobe. No changes in Radial Diffusivity (RD; measure of myelin integrity) were observed. Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructure in 22q11.2DS than in patients with schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.schres.2012.06.032en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462006/en_US
dash.licenseLAA
dc.subject22q11.2 deletion syndrome (22q11.2DS)en_US
dc.subjectschizophreniaen_US
dc.subjectDiffusion Tensor Magnetic Resonance Imaging (DT-MRI)en_US
dc.subjectfractional anisotropy (FA)en_US
dc.subjectaxial and radial diffusivityen_US
dc.subjectTract-Based Spatial Statistics (TBSS)en_US
dc.titleReduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: A pilot studyen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalSchizophrenia Researchen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-22T20:52:04Z
dc.identifier.doi10.1016/j.schres.2012.06.032*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedKucherlapati, Raju
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedKikinis, Zora
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedBouix, Sylvain
dash.contributor.affiliatedShenton, Martha


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