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dc.contributor.authorPasternak, Ofer
dc.contributor.authorShenton, Martha Elizabeth
dc.contributor.authorWestin, Carl-Fredrik
dc.date.accessioned2016-09-22T21:00:27Z
dc.date.issued2012
dc.identifier.citationPasternak, Ofer, Martha E. Shenton, and Carl-Fredrik Westin. 2012. Estimation of Extracellular Volume from Regularized Multi-Shell Diffusion MRI. Lecture Notes in Computer Science: 305–312. doi:10.1007/978-3-642-33418-4_38.en_US
dc.identifier.issn0302-9743en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28548933
dc.description.abstractDiffusion MRI measures micron scale displacement of water molecules, providing unique insight into microstructural tissue architecture. However, current practical image resolution is in the millimeter scale, and thus diffusivities from many tissue compartments are averaged in each voxel, reducing the sensitivity and specificity of the measurement to subtle pathologies. Recent studies have pointed out that eliminating the contribution of extracellular water increases the sensitivity of the diffusion measures to tissue architecture. Moreover, in brain imaging, estimation of the extracellular volume appears to indicate pathological processes such as atrophy, edema and neuroinflammation. Here we study the free-water method, which assumes a bi-tensor model. We add low b-value shells to a regular DTI acquisition and present methods to improve the estimation of the model parameters using the extra information. In addition, we define a Laplace-Beltrami regularization operator that further stabilizes the multi-shell estimation.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.relation.isversionofdoi:10.1007/978-3-642-33418-4_38en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039075/en_US
dash.licenseLAA
dc.titleEstimation of Extracellular Volume from Regularized Multi-shell Diffusion MRIen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalMedical Image Computing and Computer-Assisted Intervention – MICCAI 2012en_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-22T21:00:27Z
dc.identifier.doi10.1007/978-3-642-33418-4_38*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedWestin, Carl-Fredrik
dash.contributor.affiliatedPasternak, Ofer
dash.contributor.affiliatedShenton, Martha


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