Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection

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Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection

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Title: Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection
Author: Whitford, Thomas; Savadjiev, Peter; Kubicki, Marek R.; O, Lauren J.; Terry, Douglas P.; Bouix, Sylvain; Westin, Carl-Fredrik; Schneiderman, Jason S.; Bobrow, Laurel; Rausch, Andrew C.; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; Pantelis, Christos; Wood, Stephen J.; McCarley, Robert William; Shenton, Martha Elizabeth ORCID  0000-0003-4235-7879

Note: Order does not necessarily reflect citation order of authors.

Citation: Whitford, Thomas J., Peter Savadjiev, Marek Kubicki, Lauren J. O’Donnell, Douglas P. Terry, Sylvain Bouix, Carl-Fredrik Westin, et al. 2011. Fiber Geometry in the Corpus Callosum in Schizophrenia: Evidence for Transcallosal Misconnection. Schizophrenia Research 132, no. 1: 69–74. doi:10.1016/j.schres.2011.07.010.
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Abstract: Background—Structural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and temporoparietal cortices bilaterally have been suggested to play a role in the etiology of schizophrenia. Aims—To investigate for geometric abnormalities in these callosal fibers in schizophrenia patients using a novel Diffusion-Tensor Imaging (DTI) metric of fiber geometry named ShapeNormalized Dispersion (SHD). Methods—DTIs (3T, 51 gradient directions, 1.7 mm isotropic voxels) were acquired from 26 schizophrenia patients and 23 matched healthy controls. The prefrontal and temporoparietal fibers of the corpus callosum were extracted by means of whole-brain tractography, and their mean SHD calculated. Results—The schizophrenia patients exhibited subnormal levels of SHD in the prefrontal callosal fibers when controlling for between-group differences in Fractional Anisotropy. Reduced SHD could reflect either irregularly turbulent or inhomogeneously distributed fiber trajectories in the corpus callosum. Conclusions—The results suggest that the transcallosal misconnectivity believed to be associated with schizophrenia could arise from abnormalities in fiber geometry. These abnormalities in fiber geometry could potentially be underpinned by irregularities in the normative processes of neurodevelopment.
Published Version: doi:10.1016/j.schres.2011.07.010
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172336/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:28548983
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