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dc.contributor.authorLevitt, James Jonathan
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorNestor, Paul Gerard
dc.contributor.authorErsner-Hershfield, Hal
dc.contributor.authorWestin, C-F
dc.contributor.authorAlvarado, Jorge L.
dc.contributor.authorKikinis, Ron
dc.contributor.authorJolesz, Ferenc A.
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-23T15:18:54Z
dc.date.issued2010
dc.identifier.citationLevitt, James J., Marek Kubicki, Paul G. Nestor, Hal Ersner-Hershfield, C-F Westin, Jorge L. Alvarado, Ron Kikinis, Ferenc A. Jolesz, Robert W. McCarley, and Martha E. Shenton. 2010. A Diffusion Tensor Imaging Study of the Anterior Limb of the Internal Capsule in Schizophrenia. Psychiatry Research: Neuroimaging 184, no. 3: 143–150. doi:10.1016/j.pscychresns.2010.08.004.en_US
dc.identifier.issn0925-4927en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28548989
dc.description.abstractIntroduction—Frontal-subcortical cognitive and limbic feedback loops modulate higher cognitive functioning. The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal capsule (AL-IC). Using diffusion tensor imaging (DTI), we evaluated abnormalities in the AL-IC fiber tract in schizophrenia. Methods—16 chronic schizophrenics and 19 male, normal controls group matched for handedness, age, and parental SES, underwent DTI on a 1.5 Tesla GE system. We measured the diffusion indices, fractional anisotropy (FA) mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), and manually segmented, based on FA maps, AL-IC volume, normalized for intracranial contents (ICC). Results—Results showed a significant reduction in the ICC corrected volume of the AL-IC, in schizophrenia, but did not show diffusion measure group differences in the AL-IC in FA, MD, RD or AD. In addition, results revealed in schizophrenics, AL-IC FA correlated positively with performance on measures of spatial and verbal declarative/episodic memory, and right AL-IC ICC corrected volume correlated positively with more perseverative responses on the Wisconsin Card Sort Test (WCST). Discussion—We found a reduction in AL-IC ICC corrected volume in schizophrenia, without FA, MD, RD or AD group differences, implicating the presence of a structural abnormality in schizophrenia in this subcortical white matter region which contains important cognitive, and limbic feedback pathways which modulate prefrontal cortical function. Despite not demonstrating a group difference in FA, we found that AL-IC FA was a good predictor of spatial and verbal declarative/episodic memory performance in schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.pscychresns.2010.08.004en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043632/en_US
dash.licenseLAA
dc.subjectSchizophreniaen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectAnterior Limb of the Internal Capsuleen_US
dc.subjectthalamusen_US
dc.subjectprefrontal cortexen_US
dc.titleA diffusion tensor imaging study of the anterior limb of the internal capsule in schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalPsychiatry Research: Neuroimagingen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-23T15:18:54Z
dc.identifier.doi10.1016/j.pscychresns.2010.08.004*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedLevitt, James
dash.contributor.affiliatedJolesz, Ferenc
dash.contributor.affiliatedNestor, Paul
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedKikinis, Ron
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0001-7227-7058


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