Show simple item record

dc.contributor.authorWhitford, Thomas
dc.contributor.authorKubicki, Marek R.
dc.contributor.authorSchneiderman, Jason S.
dc.contributor.authorO, Lauren J.
dc.contributor.authorKing, Rebecca
dc.contributor.authorAlvarado, Jorge L.
dc.contributor.authorKhan, Usman
dc.contributor.authorMarkant, Douglas
dc.contributor.authorNestor, Paul Gerard
dc.contributor.authorNiznikiewicz, Margaret A.
dc.contributor.authorMcCarley, Robert William
dc.contributor.authorWestin, Carl-Fredrik
dc.contributor.authorShenton, Martha Elizabeth
dc.date.accessioned2016-09-23T15:28:47Z
dc.date.issued2010
dc.identifier.citationWhitford, Thomas J., Marek Kubicki, Jason S. Schneiderman, Lauren J. O’Donnell, Rebecca King, Jorge L. Alvarado, Usman Khan, et al. 2010. Corpus Callosum Abnormalities and Their Association with Psychotic Symptoms in Patients with Schizophrenia. Biological Psychiatry 68, no. 1: 70–77. doi:10.1016/j.biopsych.2010.03.025.en_US
dc.identifier.issn0006-3223en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:28548995
dc.description.abstractBackground—Whilst the neuroanatomical underpinnings of the functional brain disconnectivity observed in patients with schizophrenia remain elusive, white matter fiber bundles of the brain are a likely candidate given that they represent the infrastructure for long-distance neural communication. Methods—This study investigated for diffusion abnormalities in 19 patients with chronic schizophrenia (SZ), relative to 19 matched controls, across tractography-defined segments of the Corpus Callosum. Diffusion-weighted images were acquired with 51 non-collinear gradients on a 3T scanner (1.7mm isotropic voxels). The Corpus Callosum was extracted by means of whole-brain tractography and automated fiber-clustering, and was parcellated into six segments on the basis of fiber trajectories. The diffusion indices of Fractional Anisotropy (FA) and Mode were calculated for each segment. Results—Relative to the healthy controls, the SZ patients exhibited Mode increases in the Parietal fibers, suggesting a relative absence of crossing fibers. SZ patients also exhibited FA reductions in the Frontal fibers, which were underpinned by increased in Radial Diffusivity, consistent with myelin abnormalities. Significant correlations were observed between patients' degree of Reality Distortion and their FA and Radial Diffusivity, such that the most severely psychotic patients were the least abnormal in terms of their Frontal fiber diffusivity. Conclusions—The SZ patients exhibited a variety of diffusion abnormalities in the Corpus Callosum, which were related to the severity of their psychotic symptoms. To the extent that diffusion abnormalities influence axonal transmission velocities, these results provide support for those theories that emphasize neural timing abnormalities in the etiology of schizophrenia.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.biopsych.2010.03.025en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900500/en_US
dash.licenseLAA
dc.subjectschizophreniaen_US
dc.subjectcorpus callosumen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjecttractographyen_US
dc.subjectfractional anisotropyen_US
dc.subjectmodeen_US
dc.titleCorpus Callosum Abnormalities and Their Association with Psychotic Symptoms in Patients with Schizophreniaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalBiological Psychiatryen_US
dash.depositing.authorShenton, Martha Elizabeth
dc.date.available2016-09-23T15:28:47Z
dc.identifier.doi10.1016/j.biopsych.2010.03.025*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedKhan, Usman
dash.contributor.affiliatedWestin, Carl-Fredrik
dash.contributor.affiliatedNestor, Paul
dash.contributor.affiliatedWhitford, T
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedNiznikiewicz, Margaret
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0001-5705-7495
dc.identifier.orcid0000-0003-3191-2005


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record