A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala–hippocampal complex in chronic schizophrenia

DSpace/Manakin Repository

A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala–hippocampal complex in chronic schizophrenia

Citable link to this page

 

 
Title: A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala–hippocampal complex in chronic schizophrenia
Author: Yoshida, Takeshi; McCarley, Robert William; Nakamura, Motoaki; Lee, KangUk; Koo, Min-Seong; Bouix, Sylvain; Salisbury, Dean F.; Morra, Lindsay; Shenton, Martha Elizabeth ORCID  0000-0003-4235-7879 ; Niznikiewicz, Margaret A.

Note: Order does not necessarily reflect citation order of authors.

Citation: Yoshida, Takeshi, Robert W. McCarley, Motoaki Nakamura, KangUk Lee, Min-Seong Koo, Sylvain Bouix, Dean F. Salisbury, Lindsay Morra, Martha E. Shenton, and Margaret A. Niznikiewicz. 2009. A Prospective Longitudinal Volumetric MRI Study of Superior Temporal Gyrus Gray Matter and Amygdala–hippocampal Complex in Chronic Schizophrenia. Schizophrenia Research 113, no. 1: 84–94. doi:10.1016/j.schres.2009.05.004.
Full Text & Related Files:
Abstract: A progressive post-onset decrease in gray matter volume 1.5 years after first hospitalization in
schizophrenia has been shown in superior temporal gyrus (STG). However, it is still controversial whether progressive volume reduction occurs in chronic schizophrenia in the STG and amygdala– hippocampal complex (AHC), structures found to be abnormal in chronic schizophrenia. These structures were measured at two time points in 16 chronic schizophrenia patients and 20 normal comparison subjects using manual tracing with high spatial resolution magnetic resonance imaging (MRI).Average interscan interval was 3.1 years for schizophrenia patients and 1.4 years for healthy comparison subjects. Cross-sectional comparisons showed smaller relative volumes in schizophrenia compared with controls in posterior STG and AHC. An ANCOVA with interscan interval as a covariate showed there was no statistically significant progression of volume reduction in either the STG or AHC in the schizophrenia group compared with normal subjects. In the schizophrenia group, volume change in the left anterior AHC significantly correlated with PANSS negative symptoms. These data, and separately reported first episode data from our laboratory, suggest marked progression at the initial stage of schizophrenia, but less in chronic schizophrenia.
Published Version: doi:10.1016/j.schres.2009.05.004
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776716/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:28549057
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters